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In-vivo biocompatibility evaluation of cross linked cellular and acellular bovine pericardium

Indian Agricultural Research Journals

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Title In-vivo biocompatibility evaluation of cross linked cellular and acellular bovine pericardium
 
Creator PERME, HONJON
SHARMA, A K
KUMAR, NAVEEN
SINGH, HIMANI
MAITI, S K
SINGH, RAJENDRA
 
Subject Bovine pericardium
Biocompatibility
Histopathology
Rabbits
 
Description Fresh bovine pericardium from the local abattoir was cut into 2 cm x 2 cm size pieces and crosslinked with 1% solution of glutaraldehyde (GA), formaldehyde (FA), polyethylene glycol (PEG), hexamethylene di-isocyanate (HMDI) and 1-ethly-3-(3-dimethylaminoprophl)-carbodiimide (EDC). Other pieces were made acellular and then crosslinked with above chemical agents. In-vivo biocompatibility of the biomaterials was determined by subcutaneous implantation in rabbits. The implants were retrieved back on day 14, 30 and 90 post-implantation and subjected to macroscopic and microscopic evaluation. The host inflammatory response, neovasular tissue formation (fibroblasts, fine capillaries), depostition of neocollagen and penetration of host inflammatory responses in the grafted matrix were evaluated.
 
Publisher Indian Council of Agricultural Research
 
Date 2024-05-29
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier https://epubs.icar.org.in/index.php/IJAnS/article/view/76371
10.56093/ijans.v79i7.76371
 
Source The Indian Journal of Animal Sciences; Vol. 79 No. 7 (2009)
2394-3327
0367-8318
 
Language eng
 
Relation https://epubs.icar.org.in/index.php/IJAnS/article/view/76371/31872
 
Rights Copyright (c) 2017 The Indian Journal of Animal Sciences
https://creativecommons.org/licenses/by-nc-sa/4.0