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Biochemical profiles following flunixin meglumine administration in combination with hypertonic saline during endotoxic shock in buffalo calves

Indian Agricultural Research Journals

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Title Biochemical profiles following flunixin meglumine administration in combination with hypertonic saline during endotoxic shock in buffalo calves
 
Creator GHUMAN, G S
SINGH, D V
 
Subject Biochemistry
Buffalo calves
Endotoxemia
Flunixin meglumine
Hypertonic saline
 
Description Endotoxic shock was produced in 5 apparently healthy male buffalo calves aged between 4 month and 1 year by i/v infusion of Escherichia coil endotoxin @ 5 µg/kg  BW/h for 3 h. The animals were further observed for 7 days. A general hypoproteinemia was observed during endotoxin infusion along with significant hypoalbuminemia, hypoglycemia, hypofibrinogenemia, decrease in plasma globulin, creatinine while plasma blood urea nitrogen, sodium, potassium, and chloride showed nonsignificant alterations during endotoxin infusion for 3 h. All the endotoxemic buffalo calves were infused i/v hypertonic saline solution (7.2% NaCI acq.) @ 4 ml/kg BW in 6.5 min followed by flunixin meglumine @ 1.1 mg/kg BW as one time infusion and plasma proteins showed a significant decrease at 4 h but increased significantly on day 2 while albumin showed a declining trend throughtout the observation period with a signigicant fall at 4  h of start of endotoxin infusion. While plasma globulin decreased, plasma fibrin increased significantly on second and third day. Hypoglycemia continued from day 1-6 accompanied by a nonsignificant fall in BHU within normal range throughtout the 7 day observation period. The plasma creatinine increased significantly at 5 and 7 h of day 1 and on day 2 of observation. Plasma sodium and chloride did not alter significantly indicating that this treatment combination does not greatly affect the biochemical profiles during bovine endotoxemia.
 
Publisher Indian Council of Agricultural Research
 
Date 2024-05-29
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier https://epubs.icar.org.in/index.php/IJAnS/article/view/76392
10.56093/ijans.v79i7.76392
 
Source The Indian Journal of Animal Sciences; Vol. 79 No. 7 (2009)
2394-3327
0367-8318
 
Language eng
 
Relation https://epubs.icar.org.in/index.php/IJAnS/article/view/76392/31875
 
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