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Extensive variation and sub-structuring in lineage A mtDNA in Indian sheep: genetic evidence for domestication of sheep in India.

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Title Extensive variation and sub-structuring in lineage A mtDNA in Indian sheep: genetic evidence for domestication of sheep in India.
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Creator Singh S
Kumar S Jr
Kolte AP
Kumar S
 
Subject Sheep
Haplotypes
Domestic animals
Mitochondrial DNA
Species diversity
Mitochondria
Phylogenetic analysis
 
Description Not Available
Previous studies on mitochondrial DNA analysis of sheep from different regions of the world have revealed the presence of two major- A and B, and three minor- C, D and E maternal lineages. Lineage A is more frequent in Asia and lineage B is more abundant in regions other than Asia. We have analyzed mitochondrial DNA sequences of 330 sheep from 12 different breeds of India. Neighbor-joining analysis revealed lineage A, B and C in Indian sheep. Surprisingly, multidimensional scaling plot based on FST values of control region of mtDNA sequences showed significant breed differentiation in contrast to poor geographical structuring reported earlier in this species. The breed differentiation in Indian sheep was essentially due to variable contribution of two major lineages to different breeds, and sub- structuring of lineage A, possibly the latter resulting from genetic drift. Nucleotide diversity of this lineage was higher in Indian sheep (0.014 ± 0.007) as compared to that of sheep from other regions of the world (0.009 ± 0.005 to 0.01 ± 0.005). Reduced median network analysis of control region and cytochrome b gene sequences of Indian sheep when analyzed along with available published sequences of sheep from other regions of the world showed that several haplotypes of lineage A were exclusive to Indian sheep. Given the high nucleotide diversity in Indian sheep and the poor sharing of lineage A haplotypes between Indian and non-Indian sheep, we propose that lineage A sheep has also been domesticated in the east of Near East, possibly in Indian sub-continent. Finally, our data provide support that lineage B and additional lineage A haplotypes of sheep might have been introduced to Indian sub-continent from Near East, probably by ancient sea trade route.
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Date 2024-05-31T11:48:49Z
2024-05-31T11:48:49Z
2013-01-01
 
Type Journal
 
Identifier Singh S, Kumar S Jr, Kolte AP and Kumar S. 2013. Extensive variation and sub-structuring in lineage A mtDNA in Indian sheep: genetic evidence for domestication of sheep in India. PloS One, 8:e77858.
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http://krishi.icar.gov.in/jspui/handle/123456789/82946
 
Language English
 
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Publisher Not Available