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Detection of heat shock protein 70 (HSP70) in lymphocytes of broiler chickens as a biomarker of heat stress.

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Title Detection of heat shock protein 70 (HSP70) in lymphocytes of broiler chickens as a biomarker of heat stress.
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Creator Roy KS
Roy SC
Ghosh J
 
Subject heat shock protein 70 (HSP70)
 
Description Not Available
Heat shock or stress proteins (Hsp) are typically regarded as being intracellular proteins that have a range of functions including the maintenance of cellular integrity. Members of the Hsp70 family of molecules have been implicated in the processing and presentation of antigen and the cross reactivity of lymphocytes specific for pathogen-derived heat shock proteins with self Hsp70 has been suggested to be an underlying cause of certain autoimmune diseases. This study reports the presence of soluble Hsp70 in the peripheral circulation of normal individuals. Concentrations of soluble Hsp70 in females were approximately twice those in males. Circulating anti-Hsp70 antibodies were detected in all individuals assessed, but there were no differences between males and females. However, there was a significant correlation between soluble Hsp70 concentration and antibody levels in males, but not females. The physiological role for circulating heat shock proteins is intriguing, but currently unknown. These findings extend our previous observations that Hsp60 is present in the peripheral circulation and support the proposition that soluble heat shock proteins may play a regulatory role in either the prevention or protection of pathophysiological processes involving inadvertent immunorecognition or cross-recognition of heat shock proteins.
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Date 2024-05-31T12:09:59Z
2024-05-31T12:09:59Z
2013-01-01
 
Type Journal
 
Identifier Roy KS, Roy SC and Ghosh J. 2013. Detection of heat shock protein 70 (HSP70) in lymphocytes of broiler chickens as a biomarker of heat stress. Indian Veterinary Journal, 90:24-25.
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http://krishi.icar.gov.in/jspui/handle/123456789/82987
 
Language English
 
Relation Not Available;
 
Publisher Not Available