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Inhibitory effect of thymoquinone and capsaicin on Blastocystis grown in vitro

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Title Inhibitory effect of thymoquinone and capsaicin on Blastocystis grown in vitro
 
Creator Yıldız, Saadet
Aydemir, Selahattin
Ekici, Abdurrahman
Deniz, Naziye Yıldız
Yılmaz, Hasan
 
Subject Capsaicin
Gut infection
Metronidazole
Thymoquinone
 
Description 423-428
Blastocystis is enteric parasites that live in both humans and animals gastrointestinal tracts. Metronidazole (MTZ) is generally preferred in the treatment of Blastocystis infection. However, it has been shown to have teratogenic and carcinogenic potential, causing various side effects. In this study, we have made an attempt to find an alternative drug with less toxic side effects in the treatment of Blastocystis. For this purpose, the anti-Blastocystis activities of thymoquinone (TQ) and capsaicin (CAP) were evaluated in vitro. Blastocystis isolate was inoculated in Jones medium in 1.5 mL eppendorf tubes supplemented with fetal calf serum (FCS) and incubated at 37°C. The anti-Blastocystis effect of TQ and CAP was evaluated by light microscopy (LM) and scanning electron microscopy (SEM). Both TQ and CAP had anti Blastocystis effects. It was observed that 500 ug/mL of TQ and 1000 ug/mL of CAP inhibited 100% of Blastocystis growth. In the LM and SEM images, it was observed that Blastocystis treated with TQ decreased in size and CAP had an effect on the cell surface when compared to the control group. It was concluded that TQ could be a more reliable anti-Blastocystis drug compared to MTZ and CAP, but more comprehensive studies should be performed.
 
Date 2024-05-31T09:26:05Z
2024-05-31T09:26:05Z
2024-06
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/64012
https://doi.org/10.56042/ijeb.v62i06.3788
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJEB Vol.62(06) [June 2024]