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Alpha-Tocopherol ameliorates arsenic induced nephrotoxicity in Wistar rats

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Title Alpha-Tocopherol ameliorates arsenic induced nephrotoxicity in Wistar rats
 
Creator Mathur, Astha
Kumar, Navneet
Bunker, Suresh Kumar
John, Placheril Joseph
 
Subject DNA damage
Heavy metal contamination
Kidney
Oxidative stress
Soil pollution
Water pollution
Vitamin E
 
Description 400-409
α-Tocopherol’s (Vitamin E) antioxidant and anti-inflammatory properties may help reduce the progression of fibrosis in
kidney by limiting tissue damage and inflammation induced by arsenic. Knowledge of the mechanisms of action of natural
medicinal substances in arsenic toxicity will be improved by the analysis of the ameliorative effects of α-tocopherol. The
goal of the current investigation was to determine whether Vitamin E can protect rats from nephrotoxicity caused by sodium
arsenite (NaAsO2). Twenty-five Wistar rats were split into five groups viz: Group I with distilled water as control; Group II-IV
with 8.4 (Low dose)/12.3 (Moderate dose)/16.4 mg/kg NaAsO2 (High dose); and Group V as in Gr. IV + 50 mg/kg
ɑ-Tocopherol. Both the doses were administered orally to rats for 60 days. α-tocopherol decreased the concentration of
serum parameters like urea nitrogen (UN) and creatinine (CRT) whereas increased the concentration of albumin (ALB), acid
phosphatase (ACP), alkaline phosphatase (ALP) and succinic dehydrogenase (SDH) (P
 
Date 2024-05-31T09:33:29Z
2024-05-31T09:33:29Z
2024-06
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/64015
https://doi.org/10.56042/ijeb.v62i06.3751
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJEB Vol.62(06) [June 2024]