Record Details

CRISPR/cas9 cassette targeting Escherichia coliblaCTX-M specific gene of mastitis cow milk origin can alter the antibiotic resistant phenotype for cefotaxime

KRISHI: Publication and Data Inventory Repository

View Archive Info
 
 
Field Value
 
Title CRISPR/cas9 cassette targeting Escherichia coliblaCTX-M specific gene of mastitis cow milk origin can alter the antibiotic resistant phenotype for cefotaxime
Not Available
 
Creator Not Available
Rajib Deb, Parul Chaudhary, Sachinandan De
 
Subject CRISPR/cas9; mastitis; E.coli; CTX-M beta-lactamases
 
Description Not Available
CTX-M beta-lactamases are one of the most important extended spectrum beta-lactamase (ESBL) resistance enzymes found in E. coli. In the present study, 59% of E. coli isolates from mastitis cow milk were reported to be positive for ESBL types. The prevalence of beta-lactam (β-lactam) antibiotic resistance was reported to be 84%, 72.7%, 52.27%, 50%, and 45.4% for cefotaxime, cefepime, cefuroxime, oxacillin, and cephalexine, respectively. The blaCTX-M gene was found in 65% (n = 17) of the E. coli isolates when they were genotyped. Further, the use of a CRISPR/cas9 cassette to target the E. coli blaCTX-M gene revealed changes in antibiotic phenotypes for cefotaxime.
Not Available
 
Date 2024-04-08T11:25:27Z
2024-04-08T11:25:27Z
2022-03-01
 
Type Article
 
Identifier —