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Interaction of vitamin B1 and phenylalanine on the pharmacokinetics of ciprofloxacin using bioassay in rabbits

Indian Agricultural Research Journals

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Title Interaction of vitamin B1 and phenylalanine on the pharmacokinetics of ciprofloxacin using bioassay in rabbits
 
Creator ANJANEYULU, P
RAO, K V VENKATA
GULLAPUDI, SRIVIDYA
KUMAR, K ASWANI
HARSHINI, V SRI
PRATHYUSHA, G SAI
RAO, G S
TIMMAREDDY, SUMA SRI
 
Subject Ciprofloxacin, Pharmacokinetics, Phenylalanine, Rabbits, Vitamin B1
 
Description This pharmacokinetic study was carried out in rabbits following single oral administration of ciprofloxacin to study kinetic behaviour of ciprofloxacin in the presence of vitamin B1 and selected essential amino acid phenylalanine. Rabbits weighing 2-4 kg were randomly assigned to 5 groups of 6 each. Group 1 served as blank without any treatment. Group 2 served as ciprofloxacin control whereas Group 3, 4 and 5 rabbits were co-administered with thiamine (80 mg/kg), phenylalanine (48 mg/kg), combination of thiamine and phenylalanine along with ciprofloxacin (40 mg/kg) orally. Blood samples were collected at predetermined time intervals up to 24 h, and plasma was used for estimation of ciprofloxacin through bioassay. Results obtained from the experiment revealed that rabbits of Group 3, 4 and 5 showed improved levels of Cmax 4.74±0.17, 3.00±0.22, 2.18±0.12 µg/mLand AUC 20.30±5.19, 10.09±1.48, 12.85±1.34 µg.h/mL, respectively when compared to Cmax (2.10±0.14 µg/mL) and AUC (5.90±0.81 µg.h/mL) in Group II rabbits. PK-PD integration of the present study revealed that Cmax: MIC>8, AUC: MIC>125 in Group 3, 4 and 5 implying that the co-administration of vitamin B1 and phenylalanine and their combination improves the antibacterial activity and reduces the development of resistance at the selected dose of ciprofloxacin.
 
Publisher Indian Council of Agricultural Research
 
Date 2024-06-13
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier https://epubs.icar.org.in/index.php/IJAnS/article/view/147834
10.56093/ijans.v94i6.147834
 
Source The Indian Journal of Animal Sciences; Vol. 94 No. 6 (2024); 518–521
2394-3327
0367-8318
 
Language eng
 
Relation https://epubs.icar.org.in/index.php/IJAnS/article/view/147834/54793
 
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