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IN SILICO INTERACTION STUDIES OF RESVERATROL AND SILIBININ WITH DIFFERENT PROTEIN TARGETS USING MOLECULAR DOCKING

Indian Agricultural Research Journals

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Title IN SILICO INTERACTION STUDIES OF RESVERATROL AND SILIBININ WITH DIFFERENT PROTEIN TARGETS USING MOLECULAR DOCKING
 
Creator J. Venkatesh Yadav
G. V. Sudhakar Rao
N. Pazhanivel
P.L. Sujatha
 
Subject Resveratrol
Silibinin
in silico
 
Description Resveratrol and silibinin are natural phytochemicals with considerable anticancer properties. They induce apoptosis of cancer cells by binding to various protein targets. Hence in this study, in silico molecular interaction studies were made between ligand resveratrol and ligand silibinin with NF-kB p50 subunit and p65 subunit, MMP9, caspase 3 and Bax proteins. The in silico molecular interaction revealed that silibinin and resveratrol interacted with five receptors with a high binding affinity and docking score making them novel inhibitors against various types of diseases. 
 
Publisher Tamil Nadu Veterinary and Animal Sciences University
 
Date 2024-06-13
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier https://epubs.icar.org.in/index.php/IJVASR/article/view/152724
 
Source Indian Journal of Veterinary and Animal Sciences Research; Vol. 53 No. 2 (2024): IJVASR March - April 2024; 78-83
2347-2774
 
Language eng
 
Relation https://epubs.icar.org.in/index.php/IJVASR/article/view/152724/54783
 
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