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In vivo assessment of wound closure and biocompatibility of nanochitosan-polyvinylalcohol-glycerol films in experimental animal model

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Title In vivo assessment of wound closure and biocompatibility of nanochitosan-polyvinylalcohol-glycerol films in experimental animal model
Not Available
 
Creator Rosemol Jacob, M.
Amruth, P.
Akshay, P.
Stephy Rose, K.V.
Anandan, R.
Suseela Mathew
 
Subject Nanochitosan
Polyvinyl alcohol
Glycerol
Dressing films
Wound healing
 
Description Not Available
The need for innovative wound dressings has arisen due to injuries from second intention healing and their management is
associated with high costs. Modern dressings not only protect wounds but also promote proliferation of cells and tissue
regeneration. Patient compliance is crucial, ensuring that the dressing removal does not harm the newly regenerated tissue.
In this study, nano-chitosan polyvinyl alcohol- glycerol (NCH-PVA-GLY) transparent wound dressing was developed that
expedites tissue repair and can be removed through an external stimulus without disrupting the regenerated tissue. This
dressing efficiently absorbs excess wound exudates while maintaining proper hydration. Evaluation in male Wistar rats
with wounds revealed that the dressing, when applied for 16 days, resulted in minimal inflammation and denser connective
tissue compared to wounds devoid of dressings. The dressing exhibited enhanced re-epithelization and angiogenesis,
facilitating effective wound closure. The exposure of the resultant dressing, to the incised wound facilitated complete
wound closure in 16 days, suggesting the effectiveness of the dressings to cure superficial wound.
Not Available
 
Date 2024-06-07T22:16:38Z
2024-06-07T22:16:38Z
2023-12-31
 
Type Research Paper
 
Identifier Rosemol Jacob, M., Amruth, P., Akshay, P., Stephy Rose, K.V., Anandan, R. and Suseela Mathew (2023) In vivo assessment of wound closure and biocompatibility of nanochitosan-polyvinylalcohol-glycerol films in experimental animal model. International Journal of Zoology and Applied Biosciences. 8(6), 77-83.
2455-9571
http://krishi.icar.gov.in/jspui/handle/123456789/83351
 
Language English
 
Relation Not Available;
 
Publisher Rishan Publications