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Glyceraldehyde-3-Phosphate Dehydrogenase Binds with Spike Protein and Inhibits the Entry of SARS-CoV-2 into Host Cells

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Glyceraldehyde-3-Phosphate Dehydrogenase Binds with Spike Protein and Inhibits the Entry of SARS-CoV-2 into Host Cells
 
Creator Dilawari, Rahul
Chaubey, Gaurav Kumar
Modanwal, Radheshyam
Dhiman, Asmita
Talukdar, Sharmila
Kumar, Ajay
Raje, Chaaya Iyengar
Raje, Manoj
 
Subject QR Microbiology
 
Description Coronavirus disease 2019 caused by coronavirus-2 (SARS-CoV-2) has emerged as an aggressive viral pandemic. Health care providers confront a challenging task for rapid development of effective strategies to combat this and its long-term after effects. Virus entry into host cells involves interaction between receptor-binding domain (RBD) of spike (S) protein S1 subunit with angiotensin converting enzyme present on host cells. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a moonlighting enzyme involved in cellular glycolytic energy metabolism and micronutrient homeostasis. It is deployed in various cellular compartments and the extra cellular milieu. Though it is known to moonlight as a component of mammalian innate immune defense machinery, till date its role in viral restriction remains unknown.
 
Publisher KARGER
 
Date 2024
 
Type Article
PeerReviewed
 
Identifier Dilawari, Rahul and Chaubey, Gaurav Kumar and Modanwal, Radheshyam and Dhiman, Asmita and Talukdar, Sharmila and Kumar, Ajay and Raje, Chaaya Iyengar and Raje, Manoj (2024) Glyceraldehyde-3-Phosphate Dehydrogenase Binds with Spike Protein and Inhibits the Entry of SARS-CoV-2 into Host Cells. JOURNAL OF INNATE IMMUNITY, 16 (1). pp. 133-142.
 
Relation http://crdd.osdd.net/open/3112/