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Thermo-reversible self-assembled novel gellan gum hydrogels containing amino acid biogelators with antibacterial activity

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Thermo-reversible self-assembled novel gellan gum hydrogels containing amino acid biogelators with antibacterial activity
 
Creator Srivastava, Nandita
Choudhury, Anirban Roy
 
Subject QR Microbiology
 
Description In recent years, hydrogels derived from natural polymers have gained considerable attention. However, lack of mechanical strength and poor stability has become major lacuna of such systems. Scientists have attempted to resolve this problem by introducing chemical cross-linkers or synthetic modifications of natural polymers. In contrast, biological cross-linkers may be more beneficial due to their cytocompatibility and non-immunogenicity. As a biogelator, amino acids (AA) may be lucrative, yet they remain untapped till date. Present study, for the first time, reports exploitation of ʟ-Lysine, ʟ-Arginine, ʟ-Aspartic acid, and ʟ-Glutamic acid as biogelator to fabricate novel gellan gum (GG) hydrogels through green chemistry. Furthermore, as a first instance, molecular docking was applied to gain insight into the interaction between GG and AA. As predicted through docking, physical cross-linking of these hydrogels accounted for their thermo-reversibility. Moreover, to assess the suitability of prepared hydrogel for its intended use, systematic characterization studies were performed via FTIR, Raman spectroscopy, XRD, FE-SEM, and TGA. Additionally, rheological behavior of hydrogels was investigated using variety of parameters. Interestingly, GG-AA hydrogels exhibited around 99 % antibacterial activity against multidrug-resistant bacteria. According to the findings of this study, these novel hydrogels may have immense potential in the food and biomedical sectors.
 
Publisher ELSEVIER
 
Date 2024-01
 
Type Article
PeerReviewed
 
Relation https://www.sciencedirect.com/science/article/pii/S014486172300927X
http://crdd.osdd.net/open/3113/
 
Identifier Srivastava, Nandita and Choudhury, Anirban Roy (2024) Thermo-reversible self-assembled novel gellan gum hydrogels containing amino acid biogelators with antibacterial activity. CARBOHYDRATE POLYMERS, 324.