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Poly(I:C) and R848 ligands show better adjuvanticity to induce B and T cell responses against the antigen(s)

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Poly(I:C) and R848 ligands show better adjuvanticity to induce B and T cell responses against the antigen(s)
 
Creator Tandel, Nikunj
Patel, Digna
Thakkar, Mansi
Shah, Jagrut
Tyagi, Rajeev K.
Dalai, Sarat K.
 
Subject QR Microbiology
 
Description Poly(I:C) and R848, synthetic ligands that activate Toll-like receptor 3 (TLR3) and TLR7/8 respectively, have been well-established for their ability to stimulate the immune system and induce antigen-specific immune responses. These ligands are capable of inducing the production of cytokines and chemokines, and hence support the activation and differentiation of B and T cells. We saw the long-lasting and perdurable immune responses by these adjuvants essentially required for an efficacious subunit vaccine. In this study, we investigated the potential of poly(I:C) and R848 to elicit B and T cell responses to the OVA antigen. We assessed the stimulatory effects of these ligands on the immune system, their impact on B and T cell activation, and their ability to enhanced generation of B and T cells. Collectively, our findings contribute to the understanding how poly(I:C) and R848 can be utilized as an adjuvant system to enhance immune responses to protein-based subunit vaccines. In the end, this work provides insights for the development of novel vaccination strategies and improving the vaccine efficacy. Present work shall help formulate newer strategies for subunit vaccines to address the infectious diseases.
 
Publisher ELSEVIER
 
Date 2024-03
 
Type Article
PeerReviewed
 
Relation https://linkinghub.elsevier.com/retrieve/pii/S2405-8440(24)02918-9
http://crdd.osdd.net/open/3121/
 
Identifier Tandel, Nikunj and Patel, Digna and Thakkar, Mansi and Shah, Jagrut and Tyagi, Rajeev K. and Dalai, Sarat K. (2024) Poly(I:C) and R848 ligands show better adjuvanticity to induce B and T cell responses against the antigen(s). HELIYON, 10 (5).