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Association of intermediate Nugent Score and bacterial vaginosis with sexually transmitted infections and vulvovaginal candidiasis

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Association of intermediate Nugent Score and bacterial vaginosis with sexually transmitted infections and vulvovaginal candidiasis
 
Creator Sethi, Sunil
Kanaujia, Rimjhim
Yadav, Rakesh
Sharma, Nandita
Dadwal, Rajneesh
Chaudary, Hemant
Kaur, Karamjit
Saini, Aastha
Malhotra, Sakshi
Rathore, Shivali
Bagga, Rashmi
 
Subject QR Microbiology
 
Description Background Bacterial vaginosis is a common vaginal syndrome among females, which leads to significant morbidity and complications, if left untreated. The association of bacterial vaginosis with various sexually transmitted infections has been mentioned in previous literature. However, studies on the intermediate Nugent Score are lacking. This study was planned to examine the association of sexually transmitted infections with the intermediate Nugent Score. Materials and Methods The study included was conducted to include females presenting with vaginal discharge, burning micturition, itching, lower abdominal pain and infertility. The Nugent scoring was used to categorize patients into those having normal flora, intermediate or bacterial vaginosis. Conventional and molecular techniques targeting Trichomonas vaginalis, Chlamydia trachomatis, Ureaplasma urealyticum, Mycoplasma hominis, Syphilis, Neisseria gonorrhoeae and vulvovaginal candidiasis were performed. Results A total of 3,531 clinical samples were collected from females with a median age of 28.0 years. The number of patients with bacterial vaginosis and intermediate Nugent Score and positive cases were significantly higher in the 21-35 years age group (P < 0.0001). We observed that the likelihood of test results being positive for Trichomonas vaginalis was higher (P < 0.05), as the abnormality of the vaginal flora increased. Mycoplasma hominis was observed to be significantly higher in the intermediate Nugent Score group than the BV-positive patients (0.6 vs 0.2, P = 0.002). The number of vulvovaginal candidiasis cases in both the bacterial vaginosis-negative and bacterial vaginosis-positive groups were nearly the same (9.3 vs 9.8%). Limitation Individual follow-up couldn't be performed on the patients. Conclusion We observed that the dysbiosis in vaginal microbiota, with an increase in Nugent scoring, was significantly associated with an increased risk for the acquisition of sexually transmitted infections and vulvovaginal candidiasis.
 
Publisher SCIENTIFIC SCHOLAR
 
Date 2024-05
 
Type Article
PeerReviewed
 
Relation https://ijdvl.com/association-of-intermediate-nugent-score-and-bacterial-vaginosis-with-sexually-transmitted-infections-and-vulvovaginal-candidiasis/
http://crdd.osdd.net/open/3131/
 
Identifier Sethi, Sunil and Kanaujia, Rimjhim and Yadav, Rakesh and Sharma, Nandita and Dadwal, Rajneesh and Chaudary, Hemant and Kaur, Karamjit and Saini, Aastha and Malhotra, Sakshi and Rathore, Shivali and Bagga, Rashmi (2024) Association of intermediate Nugent Score and bacterial vaginosis with sexually transmitted infections and vulvovaginal candidiasis. INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY, 90 (3). pp. 296-301.