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Evolutionary trends of carbapenem-resistant and susceptible Acinetobacter baumannii isolates in a major tertiary care setting from North India

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Evolutionary trends of carbapenem-resistant and susceptible Acinetobacter baumannii isolates in a major tertiary care setting from North India
 
Creator Bansal, Kanika
Saroha, Tanu
Patil, Prashant P.
Kumar, Sanjeet
Kumar, Sunil
Singhal, Lipika
Gautam, Vikas
Patil, Prabhu B.
 
Subject QR Microbiology
 
Description Emergence of carbapenem-resistant A. baumannii (CRAB) is a global, ongoing healthcare concern. CRAB is among the topmost priority pathogens, with various studies focusing on its global population structure and resistant allelic profiles. However, carbapenem-susceptible A. baumannii (CSAB) isolates are often overlooked due to their sensitivity to beta-lactams, which can provide important insights into origin of CRAB lineages and isolates. In the present study, we report genomic investigation of CRAB and CSAB coexisting in Indian hospital setting. MLST based population structure and phylogenomics suggest they mainly follow distinct evolutionary routes forming two phylogroups. PG-I exclusively for a successful clone (ST2) of CRAB and PG-II comprises diversified CSAB isolates except PG3373, which is CRAB. Additionally, there are few CRAB isolates not belonging to PG-I and sharing clonal relationship with CSAB isolates indicating role of genome plasticity towards extensive drug resistance in the nosocomial environment. Further, genealogical analysis depicts prominent role of recombination in emergence and evolution of a major CRAB lineage. Further, CRAB isolates are enriched in resistomes as compared to CSAB isolates, which were encoded on the genomic island. Such comparative genomic insights will aid in our understanding and localized management of rapidly evolving pandrug resistant nosocomial pathogens.
 
Publisher ELSEVIER
 
Date 2024-01
 
Type Article
PeerReviewed
 
Relation https://www.sciencedirect.com/science/article/pii/S1567134823001405?via%3Dihub
http://crdd.osdd.net/open/3137/
 
Identifier Bansal, Kanika and Saroha, Tanu and Patil, Prashant P. and Kumar, Sanjeet and Kumar, Sunil and Singhal, Lipika and Gautam, Vikas and Patil, Prabhu B. (2024) Evolutionary trends of carbapenem-resistant and susceptible Acinetobacter baumannii isolates in a major tertiary care setting from North India. INFECTION GENETICS AND EVOLUTION, 117.