Record Details

Cell-Penetrating Peptides: Promising Therapeutics and Drug-Delivery Systems for Neurodegenerative Diseases

DIR@IMTECH: CSIR-Institute of Microbial Technology

View Archive Info
 
 
Field Value
 
Title Cell-Penetrating Peptides: Promising Therapeutics and Drug-Delivery Systems for Neurodegenerative Diseases
 
Creator Pirhaghi, Mitra
Mamashli, Fatemeh
Moosavi-Movahedi, Faezeh
Arghavani, Payam
Amiri, Ahmad
Davaeil, Bagher
Mohammad-Zaheri, Mahya
Mousavi-Jarrahi, Zahra
Sharma, Deepak
Langel, Ulo
Otzen, Daniel Erik
Saboury, Ali Akbar
 
Subject QR Microbiology
 
Description Currently, one of the most significant and rapidly growing unmet medical challenges is the treatment of neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD). This challenge encompasses the imperative development of efficacious therapeutic agents and overcoming the intricacies of the blood-brain barrier for successful drug delivery. Here we focus on the delivery aspect with particular emphasis on cell-penetrating peptides (CPPs), widely used in basic and translational research as they enhance drug delivery to challenging targets such as tissue and cellular compartments and thus increase therapeutic efficacy. The combination of CPPs with nanomaterials such as nanoparticles (NPs) improves the performance, accuracy, and stability of drug delivery and enables higher drug loads. Our review presents and discusses research that utilizes CPPs, either alone or in conjugation with NPs, to mitigate the pathogenic effects of neurodegenerative diseases with particular reference to AD and PD.
 
Publisher ACS
 
Date 2024-03
 
Type Article
PeerReviewed
 
Relation https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.3c01167
http://crdd.osdd.net/open/3141/
 
Identifier Pirhaghi, Mitra and Mamashli, Fatemeh and Moosavi-Movahedi, Faezeh and Arghavani, Payam and Amiri, Ahmad and Davaeil, Bagher and Mohammad-Zaheri, Mahya and Mousavi-Jarrahi, Zahra and Sharma, Deepak and Langel, Ulo and Otzen, Daniel Erik and Saboury, Ali Akbar (2024) Cell-Penetrating Peptides: Promising Therapeutics and Drug-Delivery Systems for Neurodegenerative Diseases. MOLECULAR PHARMACEUTICS, 21 (5). pp. 2097-2117.