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Dynamic monitoring of the cytotoxic effects of Cousinia iconica extracts on A549 and RL95-2 cells using the xCELLigence RTCA system

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Title Dynamic monitoring of the cytotoxic effects of Cousinia iconica extracts on A549 and RL95-2 cells using the xCELLigence RTCA system
 
Creator Paşayeva, Leyla
Arslan, Ayşe Kübra Karaboğa
Demirpolat, Eren
Tugay, Osman
 
Subject Asteraceae
Cytotoxicity
RL95-2
xCELLigence
 
Description 569-573
Asteraceae family plants have potential anticancer activity. In this study, the cytotoxic effects of C. iconica were
investigated using different tumor cell lines: Non-small lung cancer (A549) and human endometrium carcinoma cell line
(RL95-2). The cytotoxicity of the extracts was determined with MTT assay and the xCELLigence Real‑Time Cell Analyser
(RTCA). As a result, the ethyl acetate sub-extract and methanol extract of C. iconica were found cytotoxic to RL95-2 cell
line with 271 and 51 μg/mL IC50 values, respectively. According to RTCA results, the IC50 values of ethyl acetate subextract
were 44.82, 60.89, and 55.22 μg/mL and methanol extract 265.52, 250.48, and 246.65 μg/mL, for 24, 48, and 72 h
exposure, respectively. RL95-2 cells are more sensitive to ethyl acetate sub-extract than methanol extract. This study is the
known first study to show the cytotoxic effects of C. iconica extracts on both A549 and RL95-2 cell lines.
 
Date 2024-06-26T09:02:10Z
2024-06-26T09:02:10Z
2024-06
 
Type Article
 
Identifier 0975-1068 (Online); 0972-5938 (Print)
http://nopr.niscpr.res.in/handle/123456789/64085
https://doi.org/10.56042/ijtk.v23i6.11827
 
Language en
 
Relation Int Cl.24: A61K 36/00
 
Publisher NIScPR-CSIR, India
 
Source IJTK Vol.23(6) [June 2024]