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Pharmacognostic evaluation of Vasa Ghrita

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Title Pharmacognostic evaluation of Vasa Ghrita
 
Creator Shet, Nikita Mahadev
Kopardekar, Prachi Laxman
Jeedigunta, Mythili Krishna
Sardessai, Yogita
Samant, Aditya
Reddy, Srinivas
 
Subject Phytochemical analysis
Physicochemical analysis
Total phenolic content
Total flavonoid content
Vasa gritha
 
Description 550-559
Justicia adhtoda L. is a well-known plant in India traditionally used for treatment of cough and cold. Vasa ghrita
formulation is prescribed in treatment of bronchial asthma. The main aim was to develop standardization protocol for the
Vasa ghrita formulation and to establish the standard limits range by considering another two marketed formulations (RVG
and KKVG). Preliminary morphological screening was performed to describe the leaf and the formulations, in which a
range was observed especially in terms of their colour from orange-yellow (RVG), yellow (KKVG) to green-yellow
(INVG). Microscopical, phytochemical and physicochemical analysis of the leaf was in support of the literature data of
Justicia adhtoda L. A physicochemical study was performed for the formulations with pure ghee as the blank for
comparison. The parameters included, specific gravity, rancidity, melting point, saponification value, iodine value, acid
value, peroxide value, unsaponifiable matter, TLC and HPTLC, FTIR spectroscopy, total Phenolic Content and Total
Flavonoid Content. All the three formulations showed values of similar range, however, KKVG formulation was found to be
more rancid with high peroxide value (6.667±0.067) than RVG (3.4±0.116) and INVG (0.933±0.067). INVG formulation
was found to contain the maximum TPC (72.521±0.113 mg GAE/g) and TFC (14.877±0.247 mg QUE/g) values. In vitro
biological activity was carried out by studying the antioxidant potential using DPPH radical scavenging estimation; RVG
was found to have the least IC50 value (348.000±0.01 μg/mL). Microbiological load and toxicity profile of INVG
formulation were also determined to establish the safety profile of the formulation of Vasa Ghrita.
 
Date 2024-06-26T09:09:09Z
2024-06-26T09:09:09Z
2024-06
 
Type Article
 
Identifier 0975-1068 (Online); 0972-5938 (Print)
http://nopr.niscpr.res.in/handle/123456789/64087
https://doi.org/10.56042/ijtk.v23i6.11825
 
Language en
 
Relation Int Cl.24: A61K 36/00
 
Publisher NIScPR-CSIR, India
 
Source IJTK Vol.23(6) [June 2024]