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In silico study of 4-amino substituted-7-chloroquinoline derivatives as Plasmodium falciparum lactate dehydrogenase inhibitors

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Title In silico study of 4-amino substituted-7-chloroquinoline derivatives as Plasmodium falciparum lactate dehydrogenase inhibitors
 
Creator Ranade, Prasanna B
Navale, Dinesh N
Negi, Dheeraj M
Anware, Ubaidullah A
Jajoriya, Chhaya C
Mane, Pooja P
 
Subject 1LDG
4-amino substituted-7-chloroquinolines
Docking and ADME
Malaria
Plasmodium falciparum lactate dehydrogenase
 
Description 443-446
The docking between 4-amino substituted-7-chloroquinoline derivatives and Plasmodium falciparum lactate dehydrogenase were carried out. The designed 4-aminosubstitued-7-chloroquinoline derivatives show comparable dock score with chloroquine. The docking study reveals that the binding of 4-amino substituted-7-chloroquinoline derivatives and amino acids in the binding pocket of Plasmodium falciparum lactate dehydrogenase is observed. Predicted ADME properties of designed compounds are in range.
 
Date 2024-06-26T10:37:51Z
2024-06-26T10:37:51Z
2024-07
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/64093
https://doi.org/10.56042/ijbb.v61i7.953
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJBB Vol.61(07) [July 2024]