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Insights on the assessment of the potential of phytochemical chelating, protective, and detoxifying properties in managing chronic arsenic toxicity

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Title Insights on the assessment of the potential of phytochemical chelating, protective, and detoxifying properties in managing chronic arsenic toxicity
 
Creator Arati, Chettri
Chiranjeeb, Rabha
Shruti, Malik Smita
Mimangsha, Chakravarty Dorshon
Abdelmuala Abdelgani-Baraka, Gumaa
Andy, Lalremruata
Sonia, Chakma
Saeed, Ahmed-Laskar
Dinata, Roy
Roy, Vikas Kumar
Rao, KRS Sambasiva
Gurusubramanian, Guruswami
 
Subject Anti-apoptotic
Anti-inflammatory
Antioxidant
Arsenic exposure
Chelating agent
Phytochemicals
 
Description 387-400
Arsenic exposure, a global issue originating from polluted groundwater, is a significant health threat due to its
environmental and human health effects. This exposure leads to numerous illnesses (insulin resistance, cancer, bronchitis,
asthma, neurodegenerative disorders, liver and kidney dysfunction, hypertension, and cardiovascular diseases), posing
significant risks to overall health and economic and social welfare, particularly in underdeveloped nations. Arsenic-related
health issues are caused by many factors, including the formation of reactive oxygen species, oxidative damage,
inflammation, DNA damage, proteinopathies, apoptosis, and dysregulation of cell signaling pathways. Chelation therapy is
the most common method for detoxifying arsenic, but it has been linked to harmful effects such as hepatotoxicity and
neurotoxicity. Indigenous plant-based drugs have been shown to effectively relieve arsenic-mediated toxicity without
causing adverse effects. These phytochemicals aid in the elimination of As from biological systems, making them more
effective than the conventional therapeutic agents. This review provides an overview of the toxic effects of arsenic and
discusses available therapeutic strategies, emphasizing the protective and detoxifying activities of phytochemicals and
herbal drugs against arsenic. This information could help to identify new prophylactic and therapeutic formulations against
arsenic-induced toxicity.
 
Date 2024-06-26T10:56:12Z
2024-06-26T10:56:12Z
2024-07
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/64097
https://doi.org/10.56042/ijbb.v61i7.10556
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJBB Vol.61(07) [July 2024]