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Preliminary studies of antivenom and antioxidant activities of Gymnema sylvestre R.Br. leaf extracts.

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Title Preliminary studies of antivenom and antioxidant activities of Gymnema sylvestre R.Br. leaf extracts.
 
Creator Jamal, Nuzhat Ara
Saha, Kanchan
Sarkhel, Sumana
 
Subject Ayurvedic
Gurmar
Herbal
Periploca of the woods
 
Description 515-523
Medicinal plants are rich in biologically active phytoconstituents and therapeutic compounds that have wide applications
in pharmaceutical industry. The ameliorative actions of such phytochemicals could be attributed to the presence of
dietary fibre, detoxifying mediators, neuropharmacological agents, antioxidants, anticancer mediators, etc. In the present
study, we investigated the in vivo antivenom potential of Gymnema sylvestre R. Br leaf extract (GSE)in experimental
animal model. The study also investigated the antioxidant potential (in vitro) of GSE (aqueous and methanolic) along
with qualitative phytochemical constituent tests. Phytochemical tests were performed by qualitative method to detect the
presence of different phytoconstituents within the leaf. Different quantitative tests (DPPH scavenging, H2O2 scavenging,
Ferric reducing activity) were performed. The IC50 value was determined from the different concentration. To detect
the venom neutralization effects, in vitro PLA2 and in vivo lethality, haemorrhage, edema neutralization studies were
performed. Aqueous and methanolic extracts of the leaf (400 mg/kg and 100 mg/kg body wt.) provided protection
against the lethal dose of venom and showed a successful anti-hemorrhagic and edema neutralization activity against
Daboia russelli venom (DRV). In vitro PLA2 neutralization activity of the leaf showed up to 3-fold protection. Methanolic
extract exhibited the significant results in both qualitative phytochemical analysis as well as in vitro antioxidant studies. The
results specify that the leaves of Gymnema sylvestre R.Br. possess antioxidant as well as antivenom potential and could act
as a free radical inhibitor
 
Date 2024-07-09T10:38:28Z
2024-07-09T10:38:28Z
2024-07
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/64230
https://doi.org/10.56042/ijeb.v62i07.12072
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJEB Vol.62(07) [July 2024]