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Identification of Protein Drug Targets of Biofilm Formation and Quorum Sensing in Multidrug Resistant Enterococcus faecalis.

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Identification of Protein Drug Targets of Biofilm Formation and Quorum Sensing in Multidrug Resistant Enterococcus faecalis.
 
Creator Yadav, Jyoti
Das, Satyajeet
Karthikeyan, Divyapriya
Chugh, Ravneet
Jyoti, Anupam
Srivastava, Vijay Kumar
Jain, Ajay
Kumar, Sanjit
Sharma, Vinay
Kaushik, Sanket
 
Subject QR Microbiology
 
Description Enterococcus faecalis (E. faecalis) is an opportunistic multidrug-resistant (MDR) pathogen found in the guts of humans and farmed animals. Due to the occurrence of (MDR) strain there is an urgent need to look for an alternative treatment approach. E. faecalis is a Gram-positive bacterium, which is among the most prevalent multidrug resistant hospital pathogens. Its ability to develop quorum sensing (QS) mediated biofilm formation further exacerbates the pathogenicity and triggers lifethreatening infections. Therefore, developing a suitable remedy for curing E. faecalis mediated enterococcal infections is an arduous task. Several putative virulence factors and proteins are involved in the development of biofilms in E. faecalis. Such proteins often play important roles in virulence, disease, and colonization by pathogens. The elucidation of the structure-function relationship of such protein drug targets and the interacting compounds could provide an attractive paradigm towards developing structure-based drugs against E. faecalis. This review provides a comprehensive overview of the current status, enigmas that warrant further studies, and the prospects toward alleviating the antibiotic resistance in E. faecalis. Specifically, the role of biofilm and quorum sensing (QS) in the emergence of MDR strains had been elaborated along with the importance of the protein drug targets involved in both the processes.
 
Publisher BENTHAM SCIENCE
 
Date 2022-07-22
 
Type Article
PeerReviewed
 
Relation https://www.eurekaselect.com/article/123998
http://crdd.osdd.net/open/3156/
 
Identifier Yadav, Jyoti and Das, Satyajeet and Karthikeyan, Divyapriya and Chugh, Ravneet and Jyoti, Anupam and Srivastava, Vijay Kumar and Jain, Ajay and Kumar, Sanjit and Sharma, Vinay and Kaushik, Sanket (2022) Identification of Protein Drug Targets of Biofilm Formation and Quorum Sensing in Multidrug Resistant Enterococcus faecalis. Current Protein and Peptide Science , 23 (4). pp. 248-263.