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Design and synthesis of some novel 1-chloro-6-(4-(sulfonyl) piperidin-4-yl) phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-5-ones as in vitro anticancer agents
NOPR - NISCAIR Online Periodicals Repository
View Archive Info| Field | Value | |
| Title |
Design and synthesis of some novel 1-chloro-6-(4-(sulfonyl) piperidin-4-yl) phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-5-ones as in vitro anticancer agents
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| Creator |
Modugu, Narender Reddy
Siddoju, Kavitha Ega, Jagadeesh Kumar Maiti, Bhimcharan Nimmareddy, Rajashekar Reddy |
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| Subject |
Piperidinyl-pyridinones
Anti-cancer action MCF-7 breast cancer cell lines A549 lung cancer cell lines |
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| Description |
701-708
The multi-step synthesis and structural determination by 1H and 13C NMR, IR, and mass spectroscopic investigations of certain new piperidinyl-pyridines 10a-o are described in this article. Compounds 10e, 10g, 10h, 10i, 10j, and 10n show greater efficacy with Doxorubicin, which is employed as a positive control, when tested for anti-cancer activity in vitro against two cancer cell lines, A549 and MCF-7. The compound 10g shows promising action over A549 and MCF-7, with IC50 values of 16.3 and 12.3 M respectively. Other IC50 values indicate towards strong potential and were in the good promise range. |
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| Date |
2024-07-19T07:07:34Z
2024-07-19T07:07:34Z 2024-07 |
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| Type |
Article
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| Identifier |
2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/64259 https://doi.org/10.56042/ijc.v63i7.7677 |
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| Language |
en
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| Publisher |
NIScPR-CSIR,India
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| Source |
IJC Vol.63(07) [July 2024]
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