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Synthesis, characterization, and screening for the antimicrobial activity of 2-(3-(2-cyano-2-(p-tolylamino)vinyl)-1H-indol-1-yl)-N-arylacetamide derivatives

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Title Synthesis, characterization, and screening for the antimicrobial activity of 2-(3-(2-cyano-2-(p-tolylamino)vinyl)-1H-indol-1-yl)-N-arylacetamide derivatives
 
Creator Savaniya, Nikhil P
Khakhariya, Amit D
Pankhaniya, Priyanka P
Ladva, Kartik D
 
Subject Indole-3-carbaldehyde
Knoevenagel condensation
α, β-Unsaturated compounds
Antimicrobial
 
Description 673-677
Herein is described an account of research work that focuses on synthesis of some novel α,β-unsaturated compounds. To
afford 2-(3-(2-cyano-2-(p-tolylamino)vinyl)-1H-indol-1-yl)-N-arylacetamide derivatives, Knoevenagel condensation of
2-(3-formyl-1H-indol-1-yl)-N-arylacetamides and 2-cyano-N-(4-methylphenyl) acetamide have been carried out. 2-(3-
Formyl-1H-indol-1-yl)-N-arylacetamides have been easily derived by employing indole-3-carbaldehyde with 2-chloro-Narylacetamides.
All the synthesized compounds have been characterized using analytical techniques such as mass
spectrometry, Fourier transform infrared (FT-IR) spectroscopy, and nuclear magnetic resonance (NMR) spectroscopy. The
biological activity of all the synthesized compounds have been evaluated against a series of bacterial and fungal strains
(Bacillus subtilis, Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Rhizopus oryzae, and Aspergillus
parasiticus). Among the synthesized compounds 5e, 5g and 5h demonstrate excellent to moderate antibacterial activity
when compared to standard drugs such as ampicillin and streptomycin. Whereas 5e exhibits antifungal property as compared
to standard drug nystatin.
 
Date 2024-07-19T08:36:54Z
2024-07-19T08:36:54Z
2024-07
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/64263
https://doi.org/10.56042/ijc.v63i7.7350
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJC Vol.63(07) [July 2024]