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Coenzyme Q10: Regulators of Mitochondria and beyond

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Title Coenzyme Q10: Regulators of Mitochondria and beyond
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Creator Gopi Marappan
Viduranga Y. Waisundara and Miljana
 
Subject coenzyme, antioxidant, mitochondrial regulators, reduced, cholesterol synthesis, cancer
 
Description Not Available
The role of coenzyme Q10 (CoQ10) was relatively unknown except its involvement in the oxidative phosphorylation at electron transport chain. Recent researches revealed its association in conditions like maintenance of cardiac and pulmonary functions, regulation of cell proliferation to cancer prevention, etc. CoQ10, a potent lipophilic antioxidant, prevents the cellular biomolecules viz., DNA, RNA, lipid bilayers, etc. Endogenous de novo synthesis will be sufficient to maintain the daily body needs; however, synthesis showed age-dependent reduction. Commercial preparations are available for oral consumption; there are even food-grade preparations for cattle, swine and poultry. A major concern with oral intake of CoQ10 was bioavailability due to its lipophilic nature. CoQ10 has been recommended for patients under continuous statin therapy as these drugs inhibit the pathway of CoQ10 biosynthesis. The use of CoQ10 in various cardiac and tumor conditions indicates that its activity is not only due to its antioxidant activity but also due to its apoptosis property. Apart from human uses, CoQ10 is now used in food animals especially broilers as they were fed with high energy dense diet there will be leakage of electrons at electron transport chain level which adversely affects the bird’s performance and also used in treatment of ascites mortality.
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Date 2024-07-30T12:02:36Z
2024-07-30T12:02:36Z
2020-04-22
 
Type Book chapter
 
Identifier Not Available
DOI: 10.5772/intechopen.89496
http://krishi.icar.gov.in/jspui/handle/123456789/84039
 
Language English
 
Relation Not Available;
 
Publisher Not Available