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Synthesis, spectral characterization and free radical scavenging activity of zinc-genistein nano complex

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Title Synthesis, spectral characterization and free radical scavenging activity of zinc-genistein nano complex
 
Creator Gade, Ramya
Dwarampudi, L Priyanka
Swaroop, Akeya Krishna
Reddy, Duvvuru Prawin Kumar
Rao, N Srinivasa
M, Lahari Priya
 
Subject Antioxidant
Atomic Absorption Spectra
Bioavailability
Genistein
Metal flavonoid complex
Zinc
 
Description 497-503
Metal-flavanoid complexes could be of interest in the medical field. The most studied dietary phytoestrogen
(plant compounds that may resemble estrogen or modify its effects in the human body) is genistein, a naturally
occurring isoflavone. Zinc, an essential trace element, is involved in various physiological processes in the human
body and can protect against oxidative stress in certain tissues and conditions. The formation of metal flavonoid
complexes can improve the stability and bioavailability of flavonoids while influencing their biological activity. The
purpose of this study is to quantify the antioxidant capabilities of the zinc-genistein complex (ZGC) compared to
flavonoids alone. Zinc chloride and genistein were combined in a modified chelation process to create ZGC. FTIR
(Fourier transform infrared spectroscopy), UV (ultraviolet-visible spectroscopy), 1HNMR (proton nuclear magnetic
resonance), atomic absorption spectra (AAS), mass spectrometry (MS) and elemental analysis were used to
characterize the metal-flavanoid complex produced. When the characterized ZGC was tested for its antioxidant
activity, it was found that ZGC had an IC50 value of 119.32 mcg, while genistein had an IC50 value of 908.34 mcg.
This indicates that ZGC has greater antioxidant activity than genistein alone.
 
Date 2024-07-29T09:33:40Z
2024-07-29T09:33:40Z
2024-07
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/64285
https://doi.org/10.56042/ijbb.v61i8.8582
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJBB Vol.61(08) [August 2024]