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Phytochemical profiles and cytotoxicity evaluation of the ethanolic extract of Malpighia emarginata leaves: Potential for its therapeutic use

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Title Phytochemical profiles and cytotoxicity evaluation of the ethanolic extract of Malpighia emarginata leaves: Potential for its therapeutic use
 
Creator Souza, Renato Constantino dos Santos
Ferreira, Rodrigo Augusto Cristóvão
Violla, Paula Reis
Iyomasa-Pilon, Melina
Balie, Mariana
Yoshikawa, Ariane Harumi
Girol, Ana Paula
 
Subject Acerola
Alcoholic extract
DPPH
HPLC
HPTLC
Phytochemical compounds
 
Description 294-301
The search for new natural compounds with relevant therapeutic properties has increased in recent years. The objective of this study was to investigate the biological properties of the ethanolic extract of Malpighia emarginata leaves. For this, phytochemical assays, high-performance thin layer chromatography (HPTLC), high-performance liquid chromatography (HPLC), antioxidant activity analysis using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and cytotoxicity by hemolysis, and chorioallantoic membrane (CAM) studies were performed. Through qualitative analyses, phenolic compounds and alkaloids were identified, and by quantitative analyses, 92.52, 2.02, and 0.59 μg/mL were found for total flavonoids, total alkaloids, and total phenols, respectively. HPTLC showed the presence of the flavonoids catechin and gallic acid, while HPLC identified myricetin and quercetin. The extract showed a high antioxidant capacity of 80.77% by DPPH. Moreover, low cytotoxicity of the extract at 10% was observed by hemolysis and CAM assay. Our results indicate that the ethanolic extract of M. emarginata leaves is a potential candidate for therapeutic use due to the presence of important bioactive compounds, high antioxidant activity and low cytotoxicity.
 
Date 2024-08-06T05:18:56Z
2024-08-06T05:18:56Z
2024-08
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscpr.res.in/handle/123456789/64371
https://doi.org/10.56042/ijnpr.v15i2.11492
 
Language en
 
Relation Int. cl. (2021.01)− A61K 36/00, A61P, A61P 39/00
 
Publisher NIScPR-CSIR,India
 
Source IJNPR Vol.15(2) [June 2024]