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Synthesis, characterization and antimicrobial evaluation of triazole substituted pyrimidine derivatives

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Title Synthesis, characterization and antimicrobial evaluation of triazole substituted pyrimidine derivatives
 
Creator Manasa, Scandakashi
Sadanandam, Kudikala
Pinnoju, Prasad
Sarasija, Madderla
 
Subject Triazoles
Pyrimidine
Click reaction
Anti microbial activity
 
Description 807-811
The present investigation has been conducted with the purpose of creating a novel class of 1,2,3-triazole linked
pyrimidine hybrids using Cu(I)-catalyzed azide-alkyne cycloaddition (NaAAC) with high yields (80-90%) by utilizing
different poly-halogenated synthetic compounds. The structures of the newly synthesized compounds have been determined
using 1H and 13C NMR, IR, and ESI-HRMS. Evidence of antimicrobial action by the synthetically produced
pharmacologically active molecules have been provided. The efficacy of these synthetic compounds in eradicating bacteria
and fungi has been examined and compared with that of established antibiotics such as ciprofloxacin and ketoconazol,
respectively. Among all the compounds, 4a and 4f exhibit the highest levels of activity. The compounds have been tested for
their properties against Bacillus subtilis, Escherichia coli and Aspergillus flavus, Candida albicans.
 
Date 2024-08-21T05:05:26Z
2024-08-21T05:05:26Z
2024-08
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/64415
https://doi.org/10.56042/ijc.v63i8.10195
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJC Vol.63(08) [August 2024]