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Synthesis, spectral analysis and anti cancer activity of (E)-2-(4-((1-phenyl-1H- 1,2,3-triazol-4-yl)methoxy)phenyl)-1-(benzo[d]thiazol-2-yl)diazene

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Title Synthesis, spectral analysis and anti cancer activity of (E)-2-(4-((1-phenyl-1H- 1,2,3-triazol-4-yl)methoxy)phenyl)-1-(benzo[d]thiazol-2-yl)diazene
 
Creator Manasa, Guttikonda
Nukala, Satheesh Kumar
 
Subject Triazole
Benzothiazol
Molecular docking
Anticancer activity
 
Description 764-769
The present work provides a comprehensive guide to the design and high-yield synthesis of 1,2,3-triazole derivatives
employing a wide range of chemicals, bases, and catalysts. The methodology is simple, efficient, and effective. Amide coupling
reagents have been developed that are more convenient, milder, and allow for higher selectivity under mild reaction conditions.
Benzo[d]thiazol-2-amine (I) treated with NaNO2/HCl gives diazonium salt (II) and compound (II) reacts with phenol to give
intermediate (III). To get phenoxide compound (IV) compound (III) is treated with K2CO3/DMF. To get (E)-1-(benzo[d]thiazol-
2-yl)-2-(4-(prop-2-ynyloxy)phenyl)diazene (V), compound (IV) is treated with 3-bromoprop-1-yne. Derivatives of (VIa-p) are
obtained when compound (V) is treated with aniline and CuI/THF. The derivatives of (VIa-p) have shown moderate to excellent
efficacy when tested for anticancer properties against several cancer cell lines. The MCF-7 cell line is the most resistant to
compounds 6a and 6e, with an IC50 value of 1.92 and 1.99 μM respectively. The structures of the newly synthesized compounds
have been established by 1H and 13C NMR, IR, and ESI-HRMS.
 
Date 2024-08-21T05:35:21Z
2024-08-21T05:35:21Z
2024-08
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/64421
https://doi.org/10.56042/ijc.v63i8.8005
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJC Vol.63(08) [August 2024]