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Evaluation of toxic heavy metal content in marketed Ayurvedic decoctions using closed vessel microwave digestion in ICPMS

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Title Evaluation of toxic heavy metal content in marketed Ayurvedic decoctions using closed vessel microwave digestion in ICPMS
 
Creator Mohanan, Deepu
Puthiyedath, Rammanohar
G, Nandakumar
G, Minsha M
S, Sushma N
K, Shyamasundaran
 
Subject Ayurvedic herbal decoctions
Ayurvedic herbal formulations
Heavy metal contamination
Heavy metal toxicity
ICPMS
 
Description 739-746
The heavy metal toxicity of marketed Ayurvedic herbal formulations has been sporadically reported in the literature. Drakshadi (DK) and Gandharvahastadi (GK) decoctions are widely prescribed classical Ayurvedic herbal formulations. The potential adverse heavy metal toxicity due to consequent intake of DK and GK have been published in scientific papers or reported through pharmacovigilance. The objective of our investigation was to determine the presence of heavy metals in marketed DK and GK, with reference to the Ayurveda Pharmacopeia of India (API) standards. In this study, the concentration of four heavy metals, Arsenic (As), Cadmium (Cd), Lead (Pb), and Mercury (Hg) were investigated using Inductively Coupled Plasma- Mass Spectrometer (ICP-MS). These metals are not known to have any role in the pharmacological activity of these formulations. However, their presence beyond acceptable limits can have harmful consequences. Eighteen random samples each of DK and GK decoctions were collected from different pharmacy outlets, Kerala province, India. We tested 36 market samples of the above formulations for heavy metals, which were found to be within the limits prescribed by the Ayurvedic Pharmacopoeia of India. Our study suggests that heavy metal contamination of Ayurvedic formulations may not be widespread as suspected. However, continuous dynamic monitoring of Ayurvedic herbal formulations for heavy metal contamination is warranted considering the possibility of inadvertent contamination of raw drugs from environmental exposure.
 
Date 2024-08-22T06:57:41Z
2024-08-22T06:57:41Z
2024-08
 
Type Article
 
Identifier 0975-1068 (Online); 0972-5938 (Print)
http://nopr.niscpr.res.in/handle/123456789/64437
https://doi.org/10.56042/ijtk.v23i8.13114
 
Language en
 
Relation Int Cl.24: A61K 9/00, A61K 36/00
 
Publisher NIScPR-CSIR,India
 
Source IJTK Vol.23(8) [August 2024]