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Incidence of potential β-lactam resistance genes and related mobile genetic elements in uropathogenic Escherichia coli from pregnant women from Kolkata

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Title Incidence of potential β-lactam resistance genes and related mobile genetic elements in uropathogenic Escherichia coli from pregnant women from Kolkata
 
Creator Koley, Snehashis
Mukherjee, Mandira
 
Subject Antimicrobial resistance
Insertion elements
Integrons
Multidrug resistance
Plasmid replicon typing
Urinary tract infections (UTIs)
 
Description 670-677
Uropathogenic Escherichia coli (UPEC) infection is very common in pregnancy. Antimicrobial resistance (AMR) in
UPEC especially against β-lactams, limits treatment options. In this study prevalence of β-lactam resistance (BLR) and
associated genetic determinants was investigated in UPEC collected from pregnant women to delineate the underlying cause
of AMR and thus design efficacious and safe therapeutics during pregnancy. All the UPEC isolates exhibited the highest
resistance against ampicillin (100%). Phenotypically confirmed ESBL, BLIR and carbapenemase producing isolates were
63.64, 36.33 and 33.33%, respectively. Molecular studies showed co-occurrence of β-lactamase genes; blaOXA-I, blaOXA-II,
blaOXA-III, blaTEM, blaCTXM, blaNDM, blaOXA-48 in different combinations with significant (P
 
Date 2024-09-09T05:58:03Z
2024-09-09T05:58:03Z
2024-09
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/64484
https://doi.org/10.56042/ijeb.v62i08.5306
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJEB Vol.62(08) [August 2024]