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Effect of minocycline on total oxidant-antioxidant levels and penicillin induced epileptiform activity in rats

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Title Effect of minocycline on total oxidant-antioxidant levels and penicillin induced epileptiform activity in rats
 
Creator Tosun, Sinem
Kocacan, Suleyman Emre
Agar, Erdal
Ayyildiz, Mustafa
 
Subject Anticonvulsant
Electrocorticograhy
Epilepsy
Oxidative stress
Reactive oxygen species (ROS)
Seizure
Tetracycline
 
Description 635-642
Involvement of minocycline in stages of infection, neuroprotection, and inflammation is well known. However, the effect of minocycline on various rat brain regions and plasma TAS (total antioxidant status), TOS (total oxidant status) values, and electrophysiology with penicillin-induced epileptiform activity have not been investigated. Here, we examined the electrophysiological effects of different minocycline doses in an experimental epilepsy model that started locally and became generalised. We compared the tissue and plasma TAS-TOS values of the antiepileptic dose of the drug with the control, sham, and drug free epileptic groups. Electrophysiological demonstrations revealed that minocycline has an anticonvulsant effect on penicillin induced epilepsy rats (P
 
Date 2024-09-09T06:15:46Z
2024-09-09T06:15:46Z
2024-09
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/64488
https://doi.org/10.56042/ijeb.v62i08.4555
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJEB Vol.62(08) [August 2024]