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Fetal brain lesions caused by cotyledon damage of Androctonus turkiyensis venom in pregnant rats and the protective effects of the monovalent antivenom

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Title Fetal brain lesions caused by cotyledon damage of Androctonus turkiyensis venom in pregnant rats and the protective effects of the monovalent antivenom
 
Creator Alcigir, Mehmet Eray
Ozkan, Ozcan
Demirel, Murside Ayse
Turkmen, Merve Biskin
Bakir, Fatih
 
Subject Black scorpion
Immunoexpression
Oxidative stress
Pregnancy
 
Description 623-634
Scorpion envenomation is one of the severe public health problems, particularly children and pregnant women.
Increased oxidative stress in the brain during the first couple of weeks in the gestational period may limit the efficacy of
antioxidants after the scorpion envenomation. High ROS activity during brain organogenesis may damage the forebrain and
midbrain of fetuses. In this study, we examined cellular alterations in the fetal brain and cotyledon of in utero exposure to
scorpion venom and antivenom during pregnancy in rats. The study focused on establishing a correlation between fetal brain
and cotyledonary lesions due to altered oxidative stress. Eighteen pregnant Wistar albino rats were randomly divided into
three groups envenomated group (EG) by Androctonus turkiyensis Yagmur venom, antivenom group (AVG), and
physiological saline solution (1 mL, PSS: NaCl 0.85%) treated control group (CG). Pregnant rats in the EG (n=6) were
injected sublethal doses of A. turkiyensis every day between 7-13th days of pregnancy. AVG, pregnant rats (n=6) were
envenomed with A. crassicauda venom. After 4 h of each venom injection, these pregnant rats were administered a specific
antivenom. The pregnant rats in groups were operated aseptically on the 21st day of pregnancy. Ovariohysterectomy was
performed to remove the fetus with cotyledons. Fetal central nervous systems and cotyledons were examined
histopathologically and immunohistochemically. To demonstrate ROS-related damages, iNOS, 8-OHdG, 4HNE and RIPK3
were quantified and analysed statistically. As a result, expressions correspondingly to venom administration were increased
in EG despite of a decrease in AVG. In conclusion, it was found that the antivenom administration regarding scorpion
envenomations can diminish ROS-related-cotyledonary and neuronal damages.
 
Date 2024-09-09T06:18:13Z
2024-09-09T06:18:13Z
2024-09
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/64489
https://doi.org/10.56042/ijeb.v62i08.4976
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJEB Vol.62(08) [August 2024]