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Evaluation of efficacy of selected Bryophyllum pinnatum phytochemicals in hepatocarcinogenic therapy through in silico approach

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Title Evaluation of efficacy of selected Bryophyllum pinnatum phytochemicals in hepatocarcinogenic therapy through in silico approach
 
Creator Sreeja, A
Likhita, K
C H, Vidya
 
Subject Bryophyllin A
β-sitosterol
Down-stream signalling pathway
MAPK pathway
Molecular docking
PDGF pathway
Pi3k-Akt pathway
 
Description 752-759
One of the worst diseases in the world, hepatic carcinoma
requires expensive medical care upfront. Around the world,
Bryophyllum pinnatum is a plant that is used in folk medicine to
treat a variety of illnesses. Because of its abundance of active
therapeutic compounds, the plant is employed for its major
pharmacological effects. As a result, it aids in the treatment of
liver cancer, and Bryophyllum pinnatum can be used in place of
more expensive medications. In hepatocarcinogenesis disease, the
Pi3k-Akt pathway, downstream signalling pathway, MAPK
pathway, and PDGF pathway in the liver is engaged in the
invasion and spread of malignant cells. Methanolic, ethanolic, and
aqueous extracts of the phytochemicals of Bryophyllum pinnatum
were subjected to qualitative analysis, the results indicated that the
yield of phytochemicals in the ethanolic extracts was higher than
in the other two extracts. The bufadienolides, β-sitosterol and
bryophyllin A, which possess chemotherapeutic potential, were
chosen for our computational investigation to assess their ability
to interact with key signalling molecules such as VEGFR2, IGFR,
C-KIT, RET, Pi3K, C-Met, MEK-inhibitor, and PDGFR. UCSF
Chimera X was utilised to optimise the recovered molecules and
by using data from the protein databank. The interaction of
bryophyllin A and β-sitosterol, of the plant with the selected
signalling molecules was investigated using the molecular docking
tool, CB-Dock. According to the docking analysis, Bryophillin A
strongly interacted with Pi3K than the other proteins whereas
β-sitosterol showed stronger interaction with C-met.
 
Date 2024-09-09T06:32:54Z
2024-09-09T06:32:54Z
2024-09
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/64493
https://doi.org/10.56042/ijeb.v62i09.8016
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJEB Vol.62(09) [September 2024]