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Development and evaluation of gelatin/polyacrylamide/carboxymethyl tamarind kernel gum hydrogel for delivery of ampicillin sodium

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Title Development and evaluation of gelatin/polyacrylamide/carboxymethyl tamarind kernel gum hydrogel for delivery of ampicillin sodium
 
Creator Kumari, Tanuja
Nitin
Meena, Priyanka
Warkar, Sudhir G.
 
Subject Biopolymer
Drug Release
Gelatin
Hydrogel
Kinetic modelling
 
Description 681-690
Gelatin-based hydrogels, despite their excellent biocompatibility, face limitations in their utility for targeted drug release due
to low mechanical strength. Thus, this research is directed towards the fabrication of pH-responsive hydrogels based on gelatin,
polyacrylamide (PAM) and carboxymethyl tamarind kernel gum (CMTKG), followed by their loading with ampicillin sodium
drug. The hydrogel has been optimized by varying crosslinker, and initiator amounts to observe their effect on swelling. The
swelling is increased with an increase ininitiator, reaching a maximum of 1371% at pH 7.4 and 1218% at pH 1.2. The hydrogels
are analyzed through Scanning Electron Microscopy (SEM), Powder X-ray Diffraction (PXRD), and Attenuated Total
Reflection-Fourier Transform Infrared Spectroscopy (ATR-FTIR) techniques. Various parameters such as drug loading,
porosity, and gel fraction are evaluated. The in vitro drug release is evaluated in both pH 1.2 and 7.4 buffer, with higher drug
release (63.3%) observed under alkaline pH. The kinetic modeling data validates the Korsmeyer-Peppas model (R2= 0.9871) to
be the suitable model for the explanation of the drug release mechanism, suggesting the Fickian diffusion (n0.5, pH 7.4). Therefore, the Gelatin/PAM/CMTKG hydrogel shows potential for targeted release of
ampicillin sodium in response to varying pH.
 
Date 2024-09-13T11:56:31Z
2024-09-13T11:56:31Z
2024-09
 
Type Article
 
Identifier 0975-0991 (Online); 0971-457X (Print)
http://nopr.niscpr.res.in/handle/123456789/64537
https://doi.org/10.56042/ijct.v31i5.10942
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJCT Vol.31(5) [September 2024]