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Copper catalyzed arylsulfenylation of thiohydantoin using elemental sulfur and arylhalide: C-S coupling

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Title Copper catalyzed arylsulfenylation of thiohydantoin using elemental sulfur and arylhalide: C-S coupling
 
Creator Patel, Dixita J
Chikhalia, Kishor H
 
Subject Thiohydantoin
Elemental sulfur
Copper(I) iodide
C-S-C bond formation
Arylsulfenylation
 
Description 868-874
The generation and applications of carbon-sulfur (C-S) bonds in numerous natural and medicinal products have led to the
development of efficient techniques for C-S bond creation. Thiohydantoin is a privileged scaffold for biological activities,
which has aroused our interest in developing the C-S bond formation by clubbing it with another nucleus. Herein, we have
developed a C-S bond between thiohydantoin and phenyl nucleus with elemental sulfur and aryl halides using copper(I)
iodide as catalyst. Optimization has been carried out using various catalyst loadings, base, temperature and solvent. The
reaction is highly effective with broad functional group tolerance and affords yield in good to better range.
 
Date 2024-09-24T12:23:20Z
2024-09-24T12:23:20Z
2024-09
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/64593
https://doi.org/10.56042/ijc.v63i9.10771
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJC Vol.63(09) [September 2024]