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Anti-hyperalgesic activity of Ficus deltoidea in an animal model of migraine

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Title Anti-hyperalgesic activity of Ficus deltoidea in an animal model of migraine
 
Creator Salihan, Safuraa
Moklas, Mohamad Aris Mohd
Khalid, Mohamed Hanief bin
Chiromaa, Samaila Musa
Sulaiman, Mohd Roslan
Baharuldin, Mohamad Taufik Hidayat
 
Subject C-Fos
Ficus deltoidea
Hyperalgesia
Migraine
Nitroglycerin
Nociception
 
Description 426-435
Migraine is one of the most common primary headaches, causing significant morbidity to its sufferers. Ficus deltoidea
(FD) is a plant that is traditionally used in Malaysia to treat headaches. This study evaluated the potentials of FD on
attenuating hyperalgesia in nitroglycerin (NTG)-induced mice model of migraine and its related C-fos expression. This
study was divided into phases. In Phase1, NTG-induced mice model of migraine was constructed by a single dose of NTG
10 mg/kg and validated through formalin and hot plate tests, followed by evaluation of the level of C-Fos in their trigeminal
nucleus caudalis (TNC) through immunoblotting. In Phase 2, the effect of FD (50, 100, and 200 mg/kg) on hyperalgesic
behaviours and levels of C-Fos in TNC of NTG-induced mice was evaluated and compared with NTG-induced mice. The
results showed a significant increased (p
 
Date 2024-09-26T11:07:41Z
2024-09-26T11:07:41Z
2024-09
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscpr.res.in/handle/123456789/64616
https://doi.org/10.56042/ijnpr.v15i3.4915
 
Language en
 
Relation Int. cl. (2021.01)−A61K 36/00, A61K 127/00, A61P 25/06
 
Publisher NIScPR-CSIR,India
 
Source IJNPR Vol.15(3) [September 2024]