Anti-hyperalgesic activity of Ficus deltoidea in an animal model of migraine
NOPR - NISCAIR Online Periodicals Repository
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Title |
Anti-hyperalgesic activity of Ficus deltoidea in an animal model of migraine
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Creator |
Salihan, Safuraa
Moklas, Mohamad Aris Mohd Khalid, Mohamed Hanief bin Chiromaa, Samaila Musa Sulaiman, Mohd Roslan Baharuldin, Mohamad Taufik Hidayat |
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Subject |
C-Fos
Ficus deltoidea Hyperalgesia Migraine Nitroglycerin Nociception |
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Description |
426-435
Migraine is one of the most common primary headaches, causing significant morbidity to its sufferers. Ficus deltoidea (FD) is a plant that is traditionally used in Malaysia to treat headaches. This study evaluated the potentials of FD on attenuating hyperalgesia in nitroglycerin (NTG)-induced mice model of migraine and its related C-fos expression. This study was divided into phases. In Phase1, NTG-induced mice model of migraine was constructed by a single dose of NTG 10 mg/kg and validated through formalin and hot plate tests, followed by evaluation of the level of C-Fos in their trigeminal nucleus caudalis (TNC) through immunoblotting. In Phase 2, the effect of FD (50, 100, and 200 mg/kg) on hyperalgesic behaviours and levels of C-Fos in TNC of NTG-induced mice was evaluated and compared with NTG-induced mice. The results showed a significant increased (p |
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Date |
2024-09-26T11:07:41Z
2024-09-26T11:07:41Z 2024-09 |
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Type |
Article
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Identifier |
0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscpr.res.in/handle/123456789/64616 https://doi.org/10.56042/ijnpr.v15i3.4915 |
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Language |
en
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Relation |
Int. cl. (2021.01)−A61K 36/00, A61K 127/00, A61P 25/06
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Publisher |
NIScPR-CSIR,India
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Source |
IJNPR Vol.15(3) [September 2024]
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