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Anticancer activity of Origanum vulgare on lung cancer: Antiproliferative, morphological, and apoptotic effects

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Title Anticancer activity of Origanum vulgare on lung cancer: Antiproliferative, morphological, and apoptotic effects
 
Creator Yumrutas, Onder
Yumrutas, Pınar
Pehlivan, Mustafa
Kahraman, Demet
Korkmaz, Murat
Doğan, Muhittin
 
Subject Antiproliferation
Apoptosis
BAX
BCL2
Origanum vulgare
 
Description 357-363
The study was designed to determine the antiproliferation and apoptosis induction activities of Origanum vulgare hexane
extract (OVHE) on lung cancer cells A549. For this purpose, the viability and proliferation of A549 cells were determined in
lung cells after treatment of OVHE. The morphological changes of A549 cells were observed by a phase inverter
microscope. Then, the percentage of apoptotic cells was scanned by FACS staining AnnexinV/Propodium iodide.
Additionally, proapoptotic Bax and antiapoptotic Bcl-2 mRNA levels were determined by Real-time PCR. It was observed
that the viability and proliferation of A549 cells decreased after the treatment of different concentrations of OVHE.
Significant changes at the low concentration were observed in Bax and Bcl-2 mRNA levels. After the application of high
concentrations of OVHE, it was determined that A549 cells died by necrotic pathway instead of apoptosis. In conclusion,
this is thought to be the first report showing the antiproliferation and apoptotic effects of OVHE on lung cancer cells.
 
Date 2024-09-26T11:19:22Z
2024-09-26T11:19:22Z
2024-09
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscpr.res.in/handle/123456789/64622
https://doi.org/10.56042/ijnpr.v15i3.6324
 
Language en
 
Relation Int. cl. (2021.01)−A61K 36/00, A61K 36/53, A61P 35/00
 
Publisher NIScPR-CSIR,India
 
Source IJNPR Vol.15(3) [September 2024]