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Trace elements as potential biomarkers for oral squamous cell carcinoma

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Title Trace elements as potential biomarkers for oral squamous cell carcinoma
 
Creator Gadde, Samata
Upadhyayula, Maruthi Kumar
Krishna, Boggula Vamsi
Poda, S
 
Subject Copper
Iron
Magnesium
Oral squamous cell carcinoma
Serum levels
Zinc
 
Description 731-739
Oral cancer encompasses a range of tumors affecting the oral cavity, throat, and salivary glands. Oral Squamous Cell Carcinoma (OSCC) is the most common type, particularly in Southeast Asia, where it constitutes one-third of all body cancers. Patients with advanced OSCC generally experience much poorer outcomes compared to those with early-stage disease. This highlights the need for reliable biomarkers to better understand cancer development. Trace elements, crucial for various physiological processes, have been proposed as potential biomarkers for cancer due to their roles in formation and progression. This study investigates changes in serum levels of trace elements—copper, iron, zinc, and magnesium—in patients with OSCC compared to healthy age-matched controls. Conducted in Telangana, the study involved 100 OSCC patients and 100 controls. Methods used for trace element estimation include Ferrozine, DBDC, colorimeter, and calmagite. The study aims to evaluate how individual and combined risk factors, such as smoking, alcohol use, and tobacco chewing, affect trace element concentrations. Results revealed that OSCC patients had significantly higher serum copper levels, while their serum iron, zinc, and magnesium levels were lower. The study also found that combined risk factors had a greater impact on trace element levels than individual risk factors.
 
Date 2024-10-14T05:12:38Z
2024-10-14T05:12:38Z
2024-11
 
Type Article
 
Identifier 0975-0959 (Online)
0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/64713
https://doi.org/10.56042/ijbb.v61i11.12386
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJBB Vol.61(11) [November 2024]