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Evaluating the anti-cancer activity of myricetin in the management of oral cancer using in silico analysis

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Title Evaluating the anti-cancer activity of myricetin in the management of oral cancer using in silico analysis
 
Creator Sinnarkar, Shruti
Kumbhar, Gauri M
S, Ladke Vaibhav
Bhawalkar, Jitendra
Mahajan, Janhavi
 
Subject In silico analysis
Molecular docking
Myricetin
Oral cancer
PI3K-Akt signaling pathway
 
Description 659-671
Myricetin has been examined in various types of human cancer cells. However, there have been very few studies on oral
cancer. The aim of this research was to assess Myricetin's anticancer potential in oral cancer using in silico network analysis.
The in silico analysis included the determination of drug-likeness prediction, prediction of common targets between oral
cancer and myricetin, Protein-Protein Interactions (PPI), hub genes, top 10 associated pathways by Kyoto Encyclopaedia of
Genes and Genomes (KEGG) pathway and Gene Ontology (GO), and molecular docking experiments. 22 common genes
were obtained and were seen to be involved in the Ras signaling pathway, PI3K-Akt signaling pathway, chemical
carcinogenesis-ROS, Pathways in cancer, and microRNAs in cancer. The most common genes involved in the top 10
pathways were AKT1, EGFR, and MET which were seen associated with the PI3K-Akt signaling pathway which may be the
key pathway through which myricetin may aid in treating oral cancer. Molecular docking also indicated its drug-like activity
against oral cancer having a high affinity for AKT1.
According to the findings, myricetin possesses anticancer effects and has the potential to be employed as a chemotherapy
medication. The in silico approach applied in this study can serve as a paradigm for future research in the development of
effective cancer treatments.
 
Date 2024-10-14T06:09:59Z
2024-10-14T06:09:59Z
2024-10
 
Type Article
 
Identifier 0975-0959 (Online) 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/64718
https://doi.org/10.56042/ijbb.v61i11.11525
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJBB Vol.61(11) [November 2024]