Record Details

<p>Evaluating the effects of basil (<em>Ocimum basilicum</em>) in the experimental model of Alzheimer's disease in rats</p>

Online Publishing @ NISCAIR

View Archive Info
 
 
Field Value
 
Authentication Code dc
 
Title Statement <p>Evaluating the effects of basil (<em>Ocimum basilicum</em>) in the experimental model of Alzheimer's disease in rats</p>
 
Added Entry - Uncontrolled Name Yaldiz, Gulsum
Çamlica, Mahmut ; Bolu Abant İzzet Baysal University, Agriculture Faculty, Department of Field Crops
Cetinkaya, Ayhan
Erdogan Duzcu, Selma
 
Uncontrolled Index Term Alzheimer, Basil, Biochemical paramaters, Behavioral test
 
Summary, etc. <p>Alzheimer is a destructive neurodegenerative disease related to elderly age of people and it is described by memory decline, loss of cognitive and psychiatric characters. The <em>Ocimum</em> species has been used for anti-ulcerogenic, anti-inflammatory and neuroprotective activities. Therefore, this study was conducted to assess the possible role of basil (Dino cultivar) in rats against Alzheimer disease (AD). Dino cultivar was selected among the 16 basil genotypes and 4 cultivars growing under field condition in 2019 vegetation period. Some quality properties such as essential oil and its compositons and extract yield of the Dino cultivar were determined. Also, biochemical parameters and immunohistochemical findings and behavioral test were obtained in rats against AD.</p> <p>Dino had high essential oil content (1.28%), five major essential oil compositions (<em>p-</em>Allyl-anisole, linalool, trans-caryophyllene, methyl eugenol and beta bergamontene) and extract yield. The extract of the Dino cultivar was used for the biochemical parameters of the Alzheimers as total antioxidant status (TAS: 0.21-0.82 mmol/L), total oxidant status (TOS: 5.7-15.23 µmol/L), catalase (CAT: 2.17-177.31 U/L), oxidative stress index (OSI: 1.056-3.818), malondialdehyde (MDA: 0.365-2.022 mmol/L), superoxide dismutase (SOD: 194-207 U/mL) and Glutathione peroxidase1 (GPX1: 10.82-18.22 ng/mL) in experimental rats. Also, the effect of the extract was used to determine immunohistochemical findings and behavirol test results.</p> As a result of the study, the extract of the Dino cultivar had positive effect on AD depending on the examined properties. It can be suggested that basil extract can be used for the treatment of AD.<p> </p>
 
Publication, Distribution, Etc. Indian Journal of Traditional Knowledge (IJTK)
2024-10-22 12:30:21
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJTK/article/view/65060
 
Data Source Entry Indian Journal of Traditional Knowledge (IJTK); ##issue.vol## 23, ##issue.no## 10 (2024): Indian Journal of Traditional Knowledge
 
Language Note en
 
Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJTK/article/download/65060/465614717
http://op.niscair.res.in/index.php/IJTK/article/download/65060/465614718
http://op.niscair.res.in/index.php/IJTK/article/download/65060/465614720