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Synthesis, characterization, thermal aspects, density functional theory study and in vitro antibacterial evaluation of Cr(III) complexes based on pyrazolone phenylhydrazone ligands

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Title Synthesis, characterization, thermal aspects, density functional theory study and in vitro antibacterial evaluation of Cr(III) complexes based on pyrazolone phenylhydrazone ligands
 
Creator Somaiya, Chintan P
Patel, Dinesh S
Jani, Darshan H
Thanki, Drashti R
 
Subject 4-Acyl pyrazolone
Phenylhydrazone
Schiff base
Transition metal complex
DFT study
Antimicrobial activity
 
Description 1015-1027
This study examines the synthesis, characterization, computational analysis, and antibacterial activity of chromium (III) complexes with pyrazolone phenylhydrazone ligands. The ligands and their chromium (III) complexes have been synthesized and confirmed using various analytical techniques such as 1H and 13C NMR, mass spectrometry, elemental analysis, infrared spectroscopy, and UV-visible spectroscopy. The characterization of chromium (III) complexes involves elemental analysis, thermogravimetric analysis (TGA/DTG), differential scanning calorimetry (DSC), FAB mass spectrometry, and UV-visible spectroscopy, which validated their structures and properties. Additionally, the electronic properties and reactivity of the ligands and complexes have been investigated using DFT with the B3LYP/6-31G(d, p) basis set. The antimicrobial efficacy of the ligands and complexes have been tested against Gram-positive and Gram-negative bacteria, revealing significant antibacterial potential. These findings highlight the importance of pyrazolone phenylhydrazone-based chromium (III) complexes and suggest further exploration of their antimicrobial properties.
 
Date 2024-10-23T09:58:34Z
2024-10-23T09:58:34Z
2024-10
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/64735
https://doi.org/10.56042/ijc.v63i10.12704
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC Vol.63(10) [October 2024]