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Synthesis, design, and examination of the cytotoxic effects and nuclear condensation properties of novel angrographolide-vanillin-1,2,3-triazoles

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Title Synthesis, design, and examination of the cytotoxic effects and nuclear condensation properties of novel angrographolide-vanillin-1,2,3-triazoles
 
Creator Nazmi, Shaik Sonia
Kumar, A Niranjana
Bharat, Vaishnavi
Kumar, J Kotesh
Srinivas, K V N S
Bhatnagar, Ira
 
Subject Andrographis paniculata
Andrographolide
Vanillin
1,2,3-Triazole
1,3-Dipolar cycloaddition
 
Description 985-991
Andrographolide is a bioactive labdane diterpenoid found in the leaves and stems of the Andrographis paniculata plant,
which is native to South Asian countries such as India and Sri Lanka. Hybrid molecules produced by combining structural
elements or pharmacophores from two or more parent compounds retain key features from the parent compound while
potentially exhibiting novel or enhanced bioactivities. This paper presents the synthesis of andrographolide-vanillin-1,2,3-
triazole hybrid analogues through a copper-catalysed azide-alkyne cycloaddition reaction, commonly known as the "click
reaction," which enables the linkage of the three components. A series of 5 novel andrographolide-vanillin-1,2,3-triazole hybrid
molecules have been synthesized and evaluated for their cytotoxic efficacy toward HELA cell lines. The results show that
compound 7c potentially induces cytotoxicity at three different concentrations compared with the other compounds in the series.
Compared to the other analogues, 7c induced significant cytomorphological abnormalities, including nuclear condensation in
HeLa cells, as observed under both phase-contrast and fluorescence microscopes using Hoechst staining method.
 
Date 2024-10-23T10:14:53Z
2024-10-23T10:14:53Z
2024-10
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/64739
https://doi.org/10.56042/ijc.v63i10.11670
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC Vol.63(10) [October 2024]