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Apoptotic effect of antioxidants with silver and titanium dioxide nanoparticles on glioblastoma cancer cells in BALB/C mice

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Title Apoptotic effect of antioxidants with silver and titanium dioxide nanoparticles on glioblastoma cancer cells in BALB/C mice
 
Creator Khojastehkiakola, Sara
Heshmati, Masomeh
Hashemi, Mehrdad
Entezari, Maliheh
 
Subject Curcumin
Glioblastoma
miR-455
Nanoparticles
TFAM
Vitamin C
Vitamin E
 
Description 776-787
Glioblastoma is one of the most aggressive cancers affecting people globally. Numerous studies have demonstrated that nanoparticles possess potential anti-cancer properties. Nanoparticles have shown promising results in delivering drugs to the brain, although they can have side effects. One possible solution to these issues is the development of nanoparticles combined with antioxidants to improve their efficacy. This study aimed to investigate the impact of curcumin, vitamin C, and vitamin E, in combination with silver and titanium dioxide nanoparticles, on cytotoxicity and their effects on TFAM and miR-455 expression. In this study, the glioma model was induced in female BALB/C mice by implanted Gl261 cells. After two weeks, the animals were sacrificed, and tumor tissue samples were collected to evaluate apoptosis levels using MTT and flow cytometry. In addition, RNA was extracted to examine the expression of Bax, Bcl-2, miR-455, and TFAM genes in the tumor cells. Our study reveals the positive impact of combining vitamin C, vitamin E, and curcumin with Ag and TiO2 NPs on altering Bax and Bcl-2 gene expression, thereby enhancing apoptosis. The data indicated that using nanoparticles in conjunction with antioxidants decreased the levels of TFAM and miR-455, which could potentially reduce the growth of glioma tumor cells. These results suggest that combining antioxidants with Ag and TiO2 nanoparticles can significantly enhance their apoptosis-inducing effects. This combination therapy can prevent metastasis by reducing the expression of miR-455 and TFAM. Overall, this strategy improves glioma cancer therapy by targeting genes involved in tumorigenesis.
 
Date 2024-11-04T06:45:07Z
2024-11-04T06:45:07Z
2024-12
 
Type Article
 
Identifier 0975-0959 (Online), 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/64818
https://doi.org/10.56042/ijbb.v61i12.11858
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJBB Vol.61(12) [December 2024]