Record Details

Adaptive evolutionary research of the guanylate binding proteins family

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title Adaptive evolutionary research of the guanylate binding proteins family
 
Creator Yixuan, Gao
Jian, Gao
Yuqi, Gao
Xingru, Guo
Meng, An
Limeng, Gu
Jiuxia, Xie
 
Subject Guanylate binding proteins
Even-toed ungulates
Odd-toed ungulates
enetic and evolutionary characteristics
 
Description 765-775
Guanylate binding proteins (GBPs), encoded by the GBP gene family, are a multi-gene family belonging to the immune
system. However, their evolutionary characteristics in ungulates are largely unknown. In this study, we identified 259
sequences of seven GBP genes from the unannotated genomes of 37 ungulate species and performed phylogenetic and
selection pressure analyses on the GBP genes using comparative genomics approaches. Phylogenetic analysis indicated that
GBP2 and GBP3 genes may have widespread homology. Evolutionary analysis revealed significant purifying selection
acting on GBP genes during the evolution of ungulates, indicating a high degree of conservation. The GBP3 gene may play
a more important role in antiviral defense. Comparative developmental analysis between even-toed ungulates and odd-toed
ungulates showed that several members of the GBP gene family (GBP3, GBP4, GBP5, GBP6, and GBP7) exhibited stronger
positive selection pressure in even-toed ungulates. The importance of this study lies in filling knowledge gaps, analyzing
evolutionary mechanisms, exploring functional differences, and providing a foundation and guidance for future research in
related fields. This study clarifies the phylogenetic and evolutionary characteristics of the GBP gene in ungulates, providing
valuable data for further research on the evolutionary characteristics of ungulates.
 
Date 2024-11-04T06:50:14Z
2024-11-04T06:50:14Z
2024-12
 
Type Article
 
Identifier 0975-0959 (Online), 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/64819
https://doi.org/10.56042/ijbb.v61i12.11875
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJBB Vol.61(12) [December 2024]