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Synthesis and characterization of some novel N-substituted derivatives of 3-(benzo[b]thiophen-2yl)-5-(4-(substituted) phenyl)-4,5-dihydro-1H-pyrazole and its pharmacological studies

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Title Synthesis and characterization of some novel N-substituted derivatives of 3-(benzo[b]thiophen-2yl)-5-(4-(substituted) phenyl)-4,5-dihydro-1H-pyrazole and its pharmacological studies
 
Creator S, Jeyanthi
N, Muniyappan
 
Subject 2-Mercaptobenzimidazole
N-Substituted pyrazolines
Anti-inflammatory
Antioxidant
Cytotoxic studies
 
Description 1130-1140
A new series of N-substituted pyrazoline derivatives bearing 2-chloro acetyl 3a-g and benz imidazole thioether moiety
4a-g have been synthesized from substituted benzaldehyde and 2-acetyl benzo thiophene through chalcones, followed by the
cyclisation with hydrazine hydrate, acylation using chloroacetyl chloride and finally substituted with 1H-benzo[d]imidazole
thiol. All synthesized compounds 1-4a-g have been characterized by 1H and 13C NMR and mass spectroscopy. The present
work provides major scope for the synthesis of a new series of N-substituted pyrazoline derivatives bearing 2-
mercaptobenzimidazole heterocycles having various pharmacological activities associated with it like anti-oxidant, antiinflammatory,
cytotoxic properties and antimicrobial activity. Most of the compounds (3e, 4a, 4b, 4c, 4e, 4f and 4g) display
a fair degree of potent, anti-oxidant, anti-inflammatory, cytotoxic and antimicrobial properties.
 
Date 2024-11-20T04:55:26Z
2024-11-20T04:55:26Z
2024-11
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/64886
https://doi.org/10.56042/ijc.v63i11.13199
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC Vol.63(11) [November 2024]