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Platinum(II) complexes of S-benzyldithiocarbazate based Schiff base ligand: Green synthesis, characterization, cytotoxic and antioxidant assay

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Title Platinum(II) complexes of S-benzyldithiocarbazate based Schiff base ligand: Green synthesis, characterization, cytotoxic and antioxidant assay
 
Creator Jain, Akshita
Bhatnagar, Shivansh
Dave, Saurabh
Fahmi, Nighat
 
Subject S-Benzyldithiocarbazate
Pt(II) complexes
Cytotoxic activity
Antioxidant activity
 
Description 1121-1129
In the present work, benzyl-2-((5-methylthiophen-2-yl)methylene)hydrazine-1-carbothiolate ligand and its platinum(II)
complexes have been prepared by conventional and microwave assisted methods. Structural elucidation of the ligand and its
Pt(II) complexes have been performed by elemental analysis, conductance measurements, mass spectrometry, powder XRD,
FT-IR and 1H NMR spectroscopic methods. On the basis of analytical and spectral data, a square planar geometry has been
suggested for the metal complexes. Starting material (PtCl2), Ligand (LH), metal complexes [Pt(L)2] and [Pt(LH)2]Cl2 have
been screened for in vitro cytotoxic and antioxidant activity. Cytotoxic activity has been performed by MTT[3-(4,5-
dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide] assay against cervical cancer (HeLa) cell line and human breast
adenocarcinoma (MCF-7) cell line. Cisplatin has been used as the standard drug. [Pt(LH)2]Cl2 complex have shown better
cytotoxicity in comparison to ligand and other complex with IC50 values of 72.76 μM and 59.93 μM against HeLa and
MCF-7 respectively. The antioxidant activity has been measured in terms of radical scavenging ability using the stable
radical DPPH. Ascorbic acid has been used as positive control and methanol is used as negative control. The ligand shows
excellent antioxidant activity with 70.82% DPPH inhibition.
 
Date 2024-11-20T04:59:16Z
2024-11-20T04:59:16Z
2024-11
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/64887
https://doi.org/10.56042/ijc.v63i11.12888
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC Vol.63(11) [November 2024]