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Characterisation of Inactivation Domains and Evolutionary Strata in Human X Chromosome through Markov Segmentation

OAR@ICRISAT

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Relation http://oar.icrisat.org/1986/
http://dx.doi.org/10.1371/journal.pone.0007885
 
Title Characterisation of Inactivation Domains and Evolutionary Strata in Human X Chromosome through Markov Segmentation
 
Creator Kelkar, A
Thakur, V
Ramaswamy, R
Deobagkar, D
 
Subject Genetics and Genomics
 
Description Markov segmentation is a method of identifying compositionally different subsequences in a given symbolic sequence. We have applied this technique to the DNA sequence of the human X chromosome to analyze its compositional structure. The human X chromosome is known to have acquired DNA through distinct evolutionary events and is believed to be composed of five evolutionary strata. In addition, in female mammals all copies of X chromosome in excess of one are transcriptionally inactivated. The location of a gene is correlated with its ability to undergo inactivation, but correlations between evolutionary strata and inactivation domains are less clear. Our analysis provides an accurate estimate of the location of stratum boundaries and gives a high–resolution map of compositionally different regions on the X chromosome. This leads to the identification of a novel stratum, as well as segments wherein a group of genes either undergo inactivation or escape inactivation in toto. We identify oligomers that appear to be unique to inactivation domains alone.
 
Publisher PLoS ONE
 
Date 2009
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
Rights —
 
Identifier http://oar.icrisat.org/1986/1/Characterisation-of-Inactivation.pdf
Kelkar, A and Thakur, V and Ramaswamy, R and Deobagkar, D (2009) Characterisation of Inactivation Domains and Evolutionary Strata in Human X Chromosome through Markov Segmentation. PLoS ONE, 4 (11). pp. 1-8. ISSN 1932-6203