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Recent history of artificial outcrossing facilitates whole-genome association mapping in elite inbred crop varieties

OAR@ICRISAT

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Relation http://oar.icrisat.org/3024/
http://dx.doi.org/10.1073/pnas.0606133103
 
Title Recent history of artificial outcrossing facilitates whole-genome association mapping in elite inbred crop varieties
 
Creator Rostoks, N
Ramsay, L
MacKenzie, K
Cardle, L
Bhat, P R
Roose, M L
Svensson, J T
Stein, N
Varshney, R K
Marshall, D F
Graner, A
Close, T J
Waugh, R
 
Subject Genetics and Genomics
Agriculture-Farming, Production, Technology, Economics
 
Description Genomewide association studies depend on the extent of linkage disequilibrium (LD), the number and distribution of markers, and the underlying structure in populations under study. Outbreeding species generally exhibit limited LD, and consequently, a very large number of markers are required for effective whole-genome association genetic scans. In contrast, several of the world’s major food crops are self-fertilizing inbreeding species with narrow genetic bases and theoretically extensive LD. Together these are predicted to result in a combination of low resolution and a high frequency of spurious associations in LD-based studies. However, inbred elite plant varieties represent a unique human-induced pseudooutbreeding population that has been subjected to strong selection for advantageous alleles. By assaying 1,524 genomewide SNPs we demonstrate that, after accounting for population substructure, the level of LD exhibited in elite northwest European barley, a typical inbred cereal crop, can be effectively exploited to map traits by using whole-genome association scans with several
hundred to thousands of biallelic SNPs.
 
Publisher National Academy of Sciences
 
Date 2006
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
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Identifier http://oar.icrisat.org/3024/1/Recent_history_of_artificial_outcrossing_facilitates_whole-genome_association_mapping_in_elite_inbred_crop_varieties.pdf
Rostoks, N and Ramsay, L and MacKenzie, K and Cardle, L and Bhat, P R and Roose, M L and Svensson, J T and Stein, N and Varshney, R K and Marshall, D F and Graner, A and Close, T J and Waugh, R (2006) Recent history of artificial outcrossing facilitates whole-genome association mapping in elite inbred crop varieties. Proceedings of the National Academy of Sciences, 103 (49). pp. 18656-18661. ISSN 1091-6490