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Title: | Boron influences immune and antioxidant responses by modulating hepatic superoxide dismutase activity under calcium deficit abiotic stress in Wistar rats. |
Other Titles: | Not Available |
Authors: | Vijay BT Gowda NKS Mondal S Krishnamoorthy P Pal DT Mor A Karthik Bhat S Pattanaik AK |
ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
Author's Affiliated institute: | ICAR-NIANP and others |
Published/ Complete Date: | 2016-01-01 |
Project Code: | Not Available |
Keywords: | Antioxidant Boron Immunity Superoxide dismutase |
Publisher: | Europe PMC |
Citation: | Vijay BT, Gowda NKS, Mondal S, Krishnamoorthy P, Pal DT, Mor A, Karthik Bhat S and Pattanaik AK. 2016. Boron influences immune and antioxidant responses by modulating hepatic superoxide dismutase activity under calcium deficit abiotic stress in Wistar rats. Journal of Trace Elements in Medicine and Biology, 36:73-79. |
Series/Report no.: | Not Available; |
Abstract/Description: | The influence of Boron (B) supplementation on immune and antioxidant status of rats with or without abiotic stress induced by dietary calcium (Ca) restriction was studied in a feeding trial of 90 days. Wistar strain rats (3-4 wk age, n=84) were divided into 7 dietary groups (4 replicates of 3 each) viz., normal-calcium (100%) basal diet alone (NC, control) or supplemented with B at 5 (NCB-5), 10 (NCB-10), 20 (NCB-20) and 40ppm (NCB-40) levels; low-calcium (50%) basal diet alone (LC) or supplemented with 40ppm B (LCB-40). After 75 days of experimental feeding, rats were challenged with intraperitoneal injection of sheep RBCs to assess their humoral immunity. At the end of the trial, cell-mediated immunity was assessed as foot pad reaction to sheep RBCs injected into the hind leg paws. Eight rats from each group were sacrificed to collect blood for estimation of minerals and total antioxidant activity, and liver for superoxide dismutase gene expression analysis. Supplementation of graded levels of B (5, 10, 20 and 40ppm) as borax in NC diets significantly increased (P<0.01) the footpad thickness and serum total antioxidant activity, hepatic expression levels of both Cu-Zn SOD (SOD1) and Mn-SOD (SOD2) mRNAs. The erythrocytic SOD activity and humoral response did not differ significantly among the dietary groups. In Ca restricted groups, humoral immune response was significantly decreased (P<0.01) compared to control but increased (P<0.05) with 40ppm B supplementation. Serum levels of copper (Cu) and zinc (Zn) remained similar among the dietary groups, while the manganese (Mn) content was significantly decreased (P<0.01) with increased levels of dietary B. In conclusion, B supplementation increased the hepatic mRNA expression levels of both SOD isoenzymes, thereby improving the immune and antioxidant status. |
Description: | Not Available |
ISSN: | 0946-672X |
Type(s) of content: | Research Paper |
Sponsors: | Not Available |
Language: | English |
Name of Journal: | Journal of Trace Elements in Medicine and Biology |
NAAS Rating: | 9.25 |
Volume No.: | 36 |
Page Number: | 73-79 |
Name of the Division/Regional Station: | A.N. DIV |
Source, DOI or any other URL: | 10.1016/j.jtemb.2016.04.007 |
URI: | http://krishi.icar.gov.in/jspui/handle/123456789/13213 |
Appears in Collections: | AS-NIANP-Publication |
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